HtrA1在妊娠期高血压疾病患者胎盘组织中的表达

Expression and clinical significance of HtrA1 in placental tissues of patients with hypertensive disorder complicating pregnancy

目的探讨HtrA1在妊娠期高血压疾病发生发展中的表达及其临床意义。方法利用免疫组化SABC法检测正常妊娠者30例(对照组)和妊娠期高血压疾病者35例(实验组)胎盘组织中HtrA1表达,探讨HtrA1与妊娠期高血压疾病的关系。结果HtrA1在实验组胎盘组织中明显高表达,与对照组比较有显著差异(t=2.931,P<0.05);HtrA1阳性表达率随病情加重而显著增高。结论HtrA1在妊娠期高血压疾病中高表达,可能通过抑制滋养细胞的浸润能力而参与妊娠期高血压疾病发生发展。

Objective To investigate expression and clinical significance of HtrA1 in placenta of patients with hypertensive disorder complicating pregnancy （HDCP）. Methods The expression of HtrA1 in placenta of 30 normal pregnant women （ as controls） and 35 pregnant women with hypertensive disorder complicating pregnancy （in study group ） were detected by using SABC method of immunohistochemistry and relationship between expression of HtrA1 and hypertensive disorder complicating pregnancy was explored. Results The expression level of HtrAl in placental villus of these pregnant women in the study group was significantly higher than that of those pregnant women in the control group. Along with aggravation of severity of the disease, the positive expression rate of HtrA1 was increased significantly. Conclusion The increased expression of HtrA1 in placenta of patients with hypertensive disorder complicating pregnancy may be involved in pathogenesis of the disease by inhibiting infiltration of trophocvtes.