细胞因子与紫癜性肾炎研究进展

Progress in research on relationship between cytokines and Henoch-Schonlein purpura nephritis

紫癜性肾炎是儿童时期最常见的继发性肾小球疾病,严重地威胁着儿童健康。在对该病的发病机制研究中,细胞因子的作用日益受到重视。其中既包括对血清、尿液因子及其受体水平的研究,也涉及基因多态性与疾病关系的研究,一般认为白细胞介素、肿瘤坏死因子、血管内皮生长因子等与紫癜性肾炎的发病机理、临床诊断、治疗及预后均有密切关系。临床进行细胞因子检测,可作为病情及预后判断的指标,而等位基因多态性研究,为根据基因型进行治疗奠定了基础。但各细胞因子与紫癜性肾炎的定量关系及某些因子的作用机制等至今仍不甚清楚。因此,细胞因子可称目前研究热点并成为紫癜性肾炎诊断和治疗的新靶点。该文对部分细胞因子近年的研究进展进行综述。

Henoch-Schonlein purpura nephritis （HSPN） is the most common childhood secondary glomerular disease, which seriously threaten health of the children. In research on pathogenesis of this disease, the roles of cytokines attracted more and more attention. The research not only includes study on levels of cytokines both in serum and urine and their receptors, but also involves in study on relationship between gene polymorphisms and the disease. Many researches showed that interleukin （IL）, tumor necrosis factor（TNF）, vascular endothelial growth factor（VEGF） are closely related to pathogenesis, diagnosis, treatment and prognosis of HSPN. In clinic, cytokines Can be regarded as indexes to judge severity and prognosis of the disease by detecting their levels in the body. While the research on allele polymorphisms provides a basis for genotype-based treatment of the disease. However, quantitative relationship between various cytokines and HSPN, mechanisms of action of certain cytokines are still unclear till now. Therefore, cytokines have become hot-spot of the research and new target of diagnosis and treatment of HSPN. This paper reviewed progress in research on some cytokines in recent years.