当阳市乙肝母婴阻断工作分析

Block of mother-to-child vertical transmission of hepatitis B virus in Dangyang city,Hubei province

目的探讨湖北省当阳市乙肝母婴传播阻断工作状况,制定乙肝母婴传播阻断措施。方法阻断组在孕7、8、9个月分别肌注乙肝免疫球蛋白200IU/次,婴儿出生后在按常规接种乙肝疫苗3次(0、1、6个月),同时婴儿在出生24小时内1次肌注乙肝免疫球蛋白100IU;非阻断组在孕前、产时不做特殊处理,只在婴儿出生后按常规接种乙肝疫苗3次(0、1、6个月),观察婴儿乙肝病毒感染情况。结果阻断组婴儿315例有11例感染乙型肝炎病毒,感染率为3.49%;非阻断组婴儿106例有22例感染乙肝病毒,感染率为20.75%。两者经统计学检验,2χ=26.02,P<0.01,有极显著性差异。结论乙肝表面抗原阳性孕妇采取乙肝母婴传播阻断措施能减少母婴垂直传播机会。

Objective To investigate block status of mother-to-child transmission of hepatitis B in Dangyang city, Hubei province so as to work out blocking measures for mother-to-child transmission of hepatitis B virus. Methods The pregnant women in the block group were intramuscularily injected 200IU of hepatitis B immunoglobulin per time for three times at the 7th, the 8th and the 9th months of gestation respectively, and their infants routinely inoculated 100IU of hepatitis B immunoglobulin per time for three times （at 0, the first and the sixth months after birth respectively）, meanwhile, their newborns were injected intramuscularily 100 IU of hepatitis B vaccine once within 24 hours after birth. While those women and their infants in the non-block group did not receive any special interventions before parturition and within 24 hours after birth, only their infants were routinely inoculated hepatitis B vaccine for three times （at 0, the first and the sixth months after birth respectively）. HBV infection of the infants was observed. Results Of 315 infants in the block group, 11 infants infected HBV, and the infection rate was 3.49% ; of 106 infants in the non-block group, 22 infants infected HBV, and the infection rate was 20.75%. There was a very significant difference between the two groups 0（2 = 26.02, P 〈0.01 ）. Conclusion For those pregnant women with positive hepatitis B surface antigen （ HBSA ）, the blocking measures can reduce mother-to-child vertical transmission of hepatitis B virus.