期刊文献+

乳腺癌芳香化酶抑制剂治疗新进展 被引量:1

下载PDF
导出
摘要 乳腺癌是女性最常见的恶性肿瘤之一,近年来发病率逐年增高,内分泌治疗是乳腺癌最重要的治疗方法之一。第三代芳香化酶抑制剂的研发使用是当前乳腺癌内分泌治疗的重大进展。他莫昔芬(TAM)曾是早期乳腺癌辅助内分泌治疗的金标准药物,但现在它正日益受到第三代芳香化酶抑制剂的挑战,正是由于第三代芳香化酶抑制剂疗效的显著性和副反应的易控性,它正取代TAM的地位,被一些国家及国际临床指南推荐为绝经后雌、孕激素受体阳性患者的首选治疗药物。现对乳腺癌芳香化酶抑制剂治疗新进展作一综述。
作者 潘钢 周东辉
出处 《浙江医学》 CAS 2008年第3期301-303,共3页 Zhejiang Medical Journal
  • 相关文献

参考文献18

  • 1Perez E A. Appraising adjuvant aromatase inhibitor therapy[J]. Oncologist, 2006, 11 ( 10 ):1058 - 1069.
  • 2Conte P, Frassoldati A. Aromatase inhibitors in the adjuvant treatment of postmenopausal women with early breast cancer: Putting safety issues into perspective[J]. Breast J, 2007, 13(1) 28-35.
  • 3The ATAC Trialists' Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomized trial[J]. Lancet, 2002, 359:2131-2139.
  • 4The ATAC Trialists' Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer[J]. Cancer. 2003. 98:1802-1810.
  • 5Dowsett M Analysis of time to recurrence in the ATAC (Arimidex, tamoxifen, alone or in combination) trial according to estrogen receptor and progesterone receptor status[J]. Breast Cancer Res Treat, 2003,82:S7.
  • 6Ellis M J, Coop A, Singh B, et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1-and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase Ⅲ randomized trial[J]. J Clin Oncol. 2001.19:3808-3816.
  • 7Goss P E, Ingle J N, Martino S, et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer[J]. N Engl J Med, 2003, 349:1793-1802.
  • 8Thurlimann B, Keshaviah A. Breast International Group (BIG) 1-98 Collaborative Group.A comparison of letrozole and tamoxifen in postmenopausal women with eady breast cancer[J]. N Engl J Med, 2006,354(20):2200.
  • 9Ingle J N, Tu D, Pater J L, et al. Duration of letrozole treatment and outcomes in the placebo-controlled NCIC CTG MA.17 extended adjuvant therapy trial [J]. Breast Cancer Res Treat 2006. 99:295-300.
  • 10Coombes R C, Hall E, Gibson L J, et al. A randomized trial of exernestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer[J]. N Engl J Med, 2004, 350:1081-1092.

同被引文献9

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部