MMP-26和MMP-7在胃腺癌中表达的临床意义研究

Expression of MMP-26 and MMP-7 in gastric adenocarcinoma and its clinicopathological significance

目的探讨MMP-26与MMP-7在胃腺癌中的表达水平及其与各临床病理生物学特性的关系。方法采用免疫组化染色技术Envision对120例胃腺癌(60例贲门癌,60例胃窦癌)进行MMP-26和MMP-7表达的检测分析。结果MMP-26的阳性表达率为46.7%,与患者年龄、组织分类中高分化癌,贲门部位均相关,与淋巴结转移及临床分期呈负相关(P<0.01)。MMP-7的阳性表达率为53.3%,与分化程度、浸润程度、淋巴结转移及临床分期均呈正相关(P<0.05)。结论MMP-26的表达增高,提示胃腺癌的浸润和恶性程度较低,MMP-7为胃腺癌发生浸润、转移相关的重要分子学标志。同时检测MMP-7和MMP-26有助于判断胃癌的恶性程度和预后。

Objective To investigate the expression of matrix metalloproteinase-26（MMP-26） and MMP-7 in gastric adenocarcinoma and its clinicopathological significance. Methods The expression of MMP-26 and MMP-7 was examined by Envision immunohistochemistry in 120 cases of gastric adenocarcinoma including 60 cases of gastric cardia cancer and 60 cases of gastric antrum cancer. Results The positive rate of MMP-26 was 46. 7%. MMP-26 expression was significantly correlated with patients＇ age, well-differentiated cancer and cancer of gastric cardia, whereas the expression was negatively correlated with lymph node metastasis and clinical staging（P〈0.01）. The positive rate of MMP-7 was 53.3%, which was significantly correlated with well-differentiated cancer, invasion depth, lymph node metastasis and clinical staging（P〈0.05）. Conclusion The high expression of MMP-26 may indicate superficial invasion and low malignancy in gastric adenocarcinoma, but MMP-7 may be associated with tumor infiltration and metastasis in gastric cancer.