survivin、MDR_1、MRP在非小细胞肺癌中的表达及意义

Expression of survivin,MDR_1 and MRP in non-small cell lung cancer and its significance

目的探讨survivin、MDR1(P-糖蛋白)、MRP蛋白在非小细胞肺癌(NSCLC)中的表达及意义。方法观察50例非小细胞肺癌患者survivin、MDR1、MRP蛋白表达差异及相关性,分析survivin表达与预后的关系。结果78.0%的NSCLC表达survivin阳性和阴性患者1年生存率分别为43.5%、72.7%,两者差异有统计学意义(P<0.05);MDR、蛋白表达率为66.0%,与survivin蛋白显著相关(P<0.05),而MRP表达与survivin表达无明显相关(P>0.05)。结论(1)survivin蛋白在NSCLC中表达上调提示其在NSCLC发生、发展及预后中起重要作用,survivin可成为肺癌基因治疗靶点;(2)MDR1、MRP蛋白可与survivin蛋白共同存在于肺癌组织中,可能参与肿瘤耐药。

Objective To investigate the expression of survivin, MDR1 and MRP in non-small cell lung cancer （NSCLC） and its significance. Methods Survivin, MDR1 and MRP proteins were detected by immunohistochemical method in tissue specimens of 50 patients with NSCLC, and the correlation between survivin expression and clinical prognosis was analyzed. Results Survivin was expressed in 78.0% tissue samples of NSCLC patients but not detected in controls （P〈0.05）. The expression of survivin was associated with tumor differentiation and lymph node metastasis; the one-year survival rate was significantly lower in survivin-positive patients than that in surviving-negative cases （43.5% vs 72.7%,P〈0.05）. The expression of MDR1 protein was positively correlated with that of survivin（P〈0.05） ,whereas no correlation was found between the expression of MRP and survivin （P〉0.05）. Conclusion Survivin may be involved in the development of NSCLC, which might be used as a novel therapeutic target in NSCLC.