PI3K/Akt信号传导通路在妇科肿瘤中的研究进展
被引量:2
摘要
磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号传导通路具有重要的细胞调节功能,对肿瘤的发生、发展也发挥着重要的作用。本文主要探讨PI3K/Akt信号转导途径与妇科肿瘤的关系。
出处
《实用肿瘤杂志》
CAS
2008年第2期182-184,共3页
Journal of Practical Oncology
参考文献17
-
1Kim SH, Juhnn YS, Kang S, et al. Human papillomavirus 16 E5 up-regulates the expression of vascular endothelial growth factor through the activation of epidermal growth factor receptor, MEK/ ERK1,2 and PI3K/Akt [J]. Cell Mol Life Sci, 2006, 63 (7-8) : 930-938.
-
2Rao PH, Arias-Pulido H, Lu XY, et al. Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma [J]. BMC Cancer, 2004,4 (1):5 - 13.
-
3Bertelsen BI , Steine SJ. Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation [J]. Int J Cancer, 2006,118(8): 1877 -1883.
-
4Kim T J, Lee JW, Song SY,et al. Increased expression of pAKT is associated with radiation resistance in cervical cancer [J]. Korean J Gynecol Oncol, 2006,17 (1):33-38.
-
5Rincon-Arano H, Rosales R, Mora N , et al. R-Ras promotes tumor growth of cervical epithelial cells[J]. Cancer, 2003,97 (3): 575-585.
-
6Uegaki K, Kanamori Y, Kigawa J, et al. PTEN- positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma [J]. Oncol Rep, 2005, 14 (2):389-392.
-
7Uegaki K, Kanamori Y, Kigawa J, et al. PTEN is involved in the signal transduction pathway of contact inhibition in endometrial cells [J]. Cell Tissue Res, 2006,323 (3) : 523- 528.
-
8Oda K, Stokoe D, Taketani Y, et al. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma [J]. Cancer Res, 2005, 65 (23) : 10669-10673.
-
9Ward EC, Hoekstra AV, Blok LJ. The regulation and function of the forkhead transcription factor, FOXO1, is dependent on the progesterone receptor in endometrial carcinoma [J]. Endocrinology, 2007, 148 (13) :6204-6208.
-
10Kayisli O, Kayisli UA, Luleci G,et al. In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent [J]. Biol Reprod, 2004,71 (3) :714 - 721.
同被引文献22
-
1王立东.河南食管癌研究的理解和思考[J].郑州大学学报(医学版),2006,41(1):1-5. 被引量:30
-
2Fang TIAN Wei-Dong ZANG Wei-Hong HOU Hong-Tao LIU Le-Xun XUE.Nuclear Factor-κB Signaling Pathway Constitutively Activated in Esophageal Squamous Cell Carcinoma Cell Lines and Inhibition of Growth of Cells by Small Interfering RNA[J].Acta Biochimica et Biophysica Sinica,2006,38(5):318-326. 被引量:16
-
3徐晓婷,周菊英,俞志英,周乐源,秦颂兵,王利利,李莉.COX-2表达对脑胶质瘤的放射敏感性和细胞周期的影响[J].中国癌症杂志,2007,17(11):838-842. 被引量:4
-
4Kozin SV,Boucher Y,Hicklin DJ,et al.Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Research . 2001
-
5Nakata E,Mason K A,Hunter N,et al.Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors. International Journal of Radiation Oncology, Biology, Physics . 2004
-
6Gupta AK,Bakanauskas VJ,Cerniglia GJ,et al.The Ras Radiation Resistance Pathway. Cancer Research . 2001
-
7Raju U,Nakata E,Yang P,et al.In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations. International Journal of Radiation Oncology Biology Physics . 2002
-
8S Grosch,T Maier,S Schiffmann,G Geisslinger.Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. Journal of the National Cancer Institute . 2006
-
9Liu W,Chen Y,Wang W,et al.Combination of radiation and celebrex(celecoxib)reduce mammary and lung tumor growth. American Journal of Clinical Oncology . 2003
-
10Toulany M,Kehlbach R,Rodemann HP,Mozdarani H.Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling. Radiotherapy and Oncology . 2010
引证文献2
-
1牛国梁,王辉,谢荣俊,张树友.塞来昔布对乳腺癌细胞株的放射增敏作用[J].中国癌症杂志,2011,21(4):272-276. 被引量:4
-
2李建省,靳锋,王宝蕊,张竹君,丁文君,徐进,张新丽.管通方及拆方对人食管癌EC9706细胞增殖和PI3K/AKT信号通路的影响[J].甘肃科技,2017,33(9):94-96. 被引量:1
二级引证文献5
-
1刘军,门秀丽,柳雅玲,王丽.Cyclooxygenase-2抑制剂塞来昔布对乳腺癌细胞系作用的研究现状[J].泰山医学院学报,2012,33(8):633-636. 被引量:2
-
2余文韬,蒋刚.塞来昔布抗乳腺癌的临床应用[J].中国药业,2013,22(23):1-3. 被引量:1
-
3李超,成浩,肖华光,王倩.塞来昔布对人鼻咽癌CNE-2细胞放疗的增敏作用[J].现代肿瘤医学,2016,24(21):3359-3363. 被引量:2
-
4叶本模,唐春蔓,尹显飞,曾学富.塞来昔布对肿瘤放射治疗的增敏作用[J].中国肿瘤临床与康复,2017,24(7):854-856. 被引量:1
-
5刘陆,高小玲,李墨颜,刘雪宁,陈玉龙,崔姗姗.PI3K/Akt信号通路影响食管癌细胞生长的机制及中药干预作用研究进展[J].中国实验方剂学杂志,2020,26(14):217-224. 被引量:22
-
1邹绍静,陈兆峰,李敏,姬瑞,路红,郭庆红,张志镒,王娟霞,任涛文,张俐花,赵越,周永宁.PI3K/AKT2在胃癌组织表达及其与临床病理特征和生存期的关系[J].实用肿瘤杂志,2011,26(4):346-350. 被引量:22
-
2李巧云,闻立红,颜秋梅.卵巢上皮性肿瘤组织中PI3K和p-AKT蛋白的表达[J].第四军医大学学报,2007,28(10):910-912. 被引量:6
-
3赵毅,王强,赵滢,邓鑫,张天彪.磷脂酰肌醇3-激酶信号转导通路在胃肠道间质瘤中的表达及其意义[J].中华普通外科杂志,2010,25(4):326-329. 被引量:1
-
4周景师,窦科峰,李海民.肝细胞癌中粘着斑激酶表达增加及意义[J].医学研究生学报,2003,16(1):66-67. 被引量:1
-
5于庆功,刘春英,舒敏,吕梅,王媛媛,王飞.Syk基因在大肠癌组织中的表达及临床意义[J].中国误诊学杂志,2007,7(6):1177-1178. 被引量:3
-
6周涛,闫婧,李宝生.ZD1839治疗头颈部肿瘤研究进展[J].国际肿瘤学杂志,2006,33(7):558-560.
-
7陈贤亮,李良,张雅洁.Syk基因对乳腺癌血管内皮生长因子-C表达的调控作用[J].中华病理学杂志,2011,40(12):805-809. 被引量:1
-
8程玉,李建玲,刘海旺,李春辉.PI3k/Akt蛋白及mRNA在60例胃癌中的表达及意义[J].重庆医学,2015,44(10):1352-1354. 被引量:5
-
9詹丽璇,徐恩.Akt/PKB信号转导通路与脑缺血[J].国际脑血管病杂志,2009,17(2):149-152. 被引量:3
-
10袁莉,赵辉,郭晓燕.EGFR蛋白在非小细胞肺癌中的表达[J].泰山医学院学报,2013,34(8):595-597.