Gadd45β蛋白在肝细胞性肝癌中的表达及意义

Expression and significance of Gadd45beta protein in human hepatocellular carcinoma

目的检测Gadd45β蛋白在肝癌组织中的表达,探讨其与肝癌临床病理特征的关系。方法用免疫组化检测Gadd45β蛋白在50例肝细胞性肝癌及癌旁组织中的表达情况。结果Gadd45β蛋白在肝癌组织中的阳性表达率为26.0%(13/50),而在癌旁组织中的阳性表达率为82.0%(41/50),两者有显著性差异(P<0.01)。Gadd45β蛋白的表达与肝癌分化程度密切相关(P<0.05),其在高分化癌中阳性率(47.3%)显著高于在低分化癌中的阳性率(5.9%)。而Gadd45β蛋白的表达与性别、年龄以及有无淋巴结转移均无明显关系(P>0.05)。结论Gadd45β蛋白在肝细胞性肝癌组织中呈低表达,可能与肝癌的发生有关,并对肝癌恶性程度及预后判断可能有意义。

Objective To investigate the expression of Gadd45beta protein in human hepatocellular carcinoma （HCC） and its clinicopathologic significance. Methods Immunohistochemical method was used to detect the expressions of Gadd45beta in both hepatocellular carcinoma tissues and adjacent non-neoplastic liver tissues form 50 cases. Results The positive rates of Gadd45beta expression in the hepatocellular carcinoma tissues and adjacent non-neoplastic liver tissues were 26.0% （13/50） and 82.0% （41/50） respectively. There were significant difference for the positive rate between the two groups （P 〈 0.01 ）. Furthermore, the expression of Gadd45beta was closely correlated with the differentiation degree of hepatocellular carcinoma （P 〈0.05）. The positive rate of Gadd45beta in well differentiated carcinoma （47.3%） was obviously higher than that in poorly differentiated carcinoma （5.9%）. The expression of Gadd45beta was not significantly correlated with age, gender and lymph node metastasis （P 〉 0.05 ）. Conclusion Low expression of Gadd45beta protein in hepatocellular carcinoma tissues was exhibited, which may be related to hepatocarcinogenesis as well as biological behaviors and prognosis of HCC.