1Dries DR,Yu G.Assembly,maturation,and trafficking of the gamma-secretase complex in Alzheimer's disease[J].Curr Alzheimer Res,2008,5(2):132-146.
2Yu G,Nishimura M,Arawaka S,et al.Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and beta APP processing[J].Nature,2000,407(6800):48-54.
3Tolia A,De Strooper B.Structure and function of γ-secretase[J].Semin Cell Dev Biol,2009,20(2):211-218.
4Kimberly WT,LaVoie MJ,Ostaszewski BL,et al.Gamma-secretase is a membrane protein complex comprised of presenilin,nicastrin,Aph-1,and Pen-2[J].Proc Natl Acad Sci USA,2003,100(11):6382-6387.
5Confaloni A,Crestini A,Albani D,et al.Rat nicastrin gene:cDNA isolation,mRNA variants and expression pattern analysis[J].Brain Res Mol Brain Res,2005,136(1-2):12-22.
6Zhang YW,Luo WJ,Wang H,et al.Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components[J].J Biol Chem,2005,280(17):17020-17026.
7Shah S,Lee SF,Tabuchi K,et al.Nicastrin functions as a gamma-secretase-substrate receptor[J].Cell,2005,122(3):435-447.
