酒肝清胶囊对实验性大鼠酒精性脂肪肝的治疗作用

Therapeutic Effect of JiuGanQing Capsule on Experimetal Alcoholic Fatty Liver in Rats

目的:探讨酒肝清胶囊治疗酒精性脂肪肝的药理作用。方法:Wistar大鼠每次ig 56度白酒5 mL.kg-1;每日2次。连续4周,造成脂肪肝模型,大鼠肝脏经病理组织学检查,证明模型成立后,开始分组给药。模型组每日ig 56度白酒5 mL.kg-1;阳性药组每日ig 25 mg.kg-1绞股蓝总甙和56度白酒5 mL.kg-1;酒肝清胶囊高,中,低剂量组每日ig 0.6,0.3,0.15 g.kg-1酒肝清胶囊,同时ig 56度白酒5 mL.kg-1,每日1次,连续4周。取血清,测定谷丙转氨酶(ALT)、谷草转氨酶(AST)、甘油三酯(TG)、总胆固醇(T-CHO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、总蛋白(TP)、白蛋白(Alb)和肿瘤坏死因子(TNF-α)含量。取肝脏称重,计算肝脏系数(g.100 g-1体重)。取肝左叶,测定TG,TC,MDA,ALT,AST,SOD活性。取肝右叶,做病理检查。结果:酒肝清胶囊灌胃给药,可以显著降低酒精性脂肪肝大鼠TG,TC,ALT,AST,MDA和TNF-α含量,增加ALB含量和SOD活性。结论:酒肝清胶囊对大鼠实验性酒精肝有明显的治疗作用。

Objective：To investigate the effect of Jiuganqing capsule on alcoholic fatty liver. Methods：Alcoholic fatty liver of Wister rat was in duced by ig 56° alcohol liquid 5 mL·kg^-1 twice a day for 4 week. The model is determined by histopathologic examination. The model group was given alcohol liquid as mentioned above. The masculine drug group was given Gypenosides ig 25 mg·kg^-1 daily and alcohol as the model. Jiuganqing capsule high, middle and low dose-group was separately give ig 0.6,0.3,0.15 g·kg^-1 and alcohol as the modes for 4 week. The content of ALT, AST, TG, T-CHO, SOD, MDA, TP, Alb and TNF-α in serum were detected. The hepatic index was calculated by weighing liver. The activity of TG, TC, MDA, ALT, AST and SOD in hepatic hemogenate were detected. Results： Jiuganqing capsule can obviously reduce activity of ALT,AST and the content of T-CHO,TG,MDA, TNF-α but increase the content of Alb and activity of SOD. Conclusion：Jiuganqing capsule has obviously therapeutic effect on alcoholic fatty liver in rat.