LNG-IUS治疗子宫腺肌病的中远期临床观察

THE MEDIUM-TERM AND LONG-TERM CLINICAL EFFECT OF LEVONORGESTREL-RELEASING INTRA-UTERINE SYSTEM IN THE TREATMENT OF ADENOMYOSIS

目的观察和探讨LNG—IUS治疗子宫腺肌病的中远期临床疗效和安全性。方法对33例子宫腺肌病患者放置LNG—IUS并对其放环后第2～5年逐年随诊观察。结果LNG—IUS治疗子宫腺肌病第2～5年内，痛经、月经量多等症状持续明显改善，生活质量相应提高，一定程度上缩小子宫体积，有效控制子宫腺肌病的病程进展。期间未发现其对患者肝功能、血脂代谢及性激素分泌有明显影响。中远期的不良反应主要为阴道少量点滴出血，患者多能耐受。结论宫内放置LNG—IUS用于治疗子宫腺肌病是一种长效稳定、经济安全的保守性治疗方法。

Objective Observe and evaluate the medium - term and long - term clinical efficacy and security of a levonorgestrel - releasing intrauterine system for adenomyosis. Methods LNG - IUS were inserted in 33 patients diagnosed as adenomyosis and follow - up observation was in process in 1 - 5 year respectively. Results In the 2 - 5th year of LNG - IUS placed in the uterine cavity of patients with adenomyosis, sustainable effectively eased dysmenorrhea, reduced menstrual flow, correspondingly improved the quality of life, to some extent shrinked uterine volume, and effectively controlled the disease progression. Conclusion Inserting LNG - IUS in uterus is an acceptable conservative treatment of adenomyosis with long - term effect and security.