静息态下不同性别抑郁症患者脑功能及其差异的fMRI研究

Brain Function in Depressed Patients of Different Gender and Their Differences:A Resting-State fMRI Study

目的:探讨静息态下不同性别抑郁症患者的脑功能特点及其差异。方法:男女抑郁患者各11例及性别、年龄、受教育程度均与患者匹配的健康对照22例参加静息态fMRI扫描。结果:男抑郁组较男对照组右额上回、双侧额中回、左楔前叶、右前扣带回背侧、左后扣带回、右海马旁回及右尾状核区域局部一致性增高(K值≥10,P<0.005)。女抑郁组较女对照组右额中回、左额下回、右后扣带回及左尾状核区域局部一致性增高(K≥10,P<0.005)。男抑郁组较女抑郁组左顶下小叶、右颞上回、右颞中回区域局部一致性增高(K≥10,P<0.005),而女抑郁组未显示较男抑郁组局部一致性的增高;女对照组较男对照组左尾状核局部一致性增高(K≥10,P<0.005),而男对照组未显示较女对照组局部一致性的增高。结论:进一步支持了既往提出的抑郁症存在的病理神经环路(边缘-皮层-纹状体-苍白球-丘脑)的假说,并认为静息态下抑郁症患者的脑功能具有性别差异。

Objective ：To explore the gender difference of brain function in depressed patients and compare the results with normal controls. Methods： 11 male depressed patients, 11 female depressed patients and 22 gender-, age-, and education-matched normal controls experienced resting-state fMRI scans. Results：Compared with male controls, the male depressed patients showed increased ReHo （regional homogeneity ） in right superior frontal gyrus, bilateral middle frontal gyrus, left precuneus, right dorsal anterior cingulate gyrus, left posterior cingulate gyrus, right parahip- pocampal gyrus and right caudate （K≥ 10, P 〈 0. 005 ） ; Compared with female controls, the female depressed patients showed increased ReHo in right middle frontal gyrus, left inferior frontal gyrus, right posterior cingulate gyrus and left caudate （K≥ 10, P 〈 0. 005 ）. Compared with female depressed patients, the male depressed patients showed increased ReHo in left inferior parietal lobule, right superior, middle temporal gyrus （ K ≥10, P 〈 0. 005 ）, but the female depressed patients didnt showed higher ReHo than male depressed patients ; Compared with male controls, the female controls showed increased ReHo in left caudate （ K≥ 10, P 〈 0. 005 ）. Conclusion ： Our study provided additional evidence for the hypothesis that involvement of limbic-cortical-striatal-pallidal-thalamic circuit in the pathophysiology of depression, and suggested that gender differences exist in the brain function in depressed patients during resting state.