摘要
目的:探讨胰岛素样生长因子结合蛋白-2(insulin- like growth factor binding protein-2,IGFBP-2)、胰岛素样生长因子1(insulin-like growth factor 1,IGFI)和胰岛素样生长因子1受体(insulin-like growth factor 1 receptor,IGFIR)在胃癌组织中的表达及意义。方法:应用免疫组化法检测了60例胃癌以及20例浅表性胃炎的胃粘膜组织中IGFBP-2、IGFI和IGFIR的表达情况并分析它们与生物学行为预后的关系。结果:胃癌组织中IGFBP-2、IGFI、IGFIR阳性率分别为70%、63.3%、65%,与对照组比较差异有统计学意义(P<0.01)。结论:IGFBP-2、IGFI、IGFIR在胃癌组织中均有较高表达,三者表达有相关性.可能存在共同的激活机制,在胃癌的发生、发展及转归过程中具有一定的意义。
Objective: To investigate the expression and significance of IGFBP-2, IGFI and IGFIR in gastric carcinoma. Methods: The expression of IGFBP-2, IGFI and IGFIR in 60 cases of gastric cancer samples and 20 cases of superficial gastritis tissues was determined by SP immunohistochemistry technique for observing the relationship among IGF- BP-2, IGFI and IGFIR and prognostic evaluation in biological behavior. Results: The positive rates of IGFBP-2, IGFI and IGFIR in gastric carcinoma accounted for 70%, 63.3% and 65%, respectively, which showed significant difference compared with control group( P 〈 0.01 ). Conclusion: The higher expression of IGFBP-2, IGFI and IGFIR in gastric carcinoma with a positive correlation among them shows that there is certain common activation mechanism in the three factors and they may contribute to the occurrence, development and turnover of gastric carcinoma.
出处
《皖南医学院学报》
CAS
2008年第2期98-101,共4页
Journal of Wannan Medical College