注射用炎琥宁与注射用头孢拉定的配伍稳定性考察

Compatible Stability of Andrographolide for Injection with Cefradine for Injection

目的:考察注射用炎琥宁与注射用头孢拉定在0·9%氯化钠注射液中的配伍稳定性。方法:采用高效液相色谱法测定注射用炎琥宁与注射用头孢拉定配伍后的含量变化,观察和检测配伍液的外观及pH值变化。结果:6h内配伍液外观、pH值及含量均无明显变化。结论:注射用炎琥宁与注射用头孢拉定在0·9%氯化钠注射液中配伍后于室温下6h内可使用。

OBJECTIVE： To study the compatible stability of andrographolide for injection with cefradine for injection in 0.9% sodium chloride injection .METHODS：The content of the mixture in 0.9% sodium chloride injection were determined at different time by HPLC; the appearance of the solution was observed and its pH value was determined.RESULTS： No significant differences were noted for the mixture in appearance, pH value and contents within 6 hours after mixing.CONCLUSION： The mixture of cefradine for injection and andrographolide for injection in 0.9% sodium chloride injection can be mixed to use within 6 h under room temperature.