摘要
目的观察脑出血患者1d、3d、7d、14d血清中可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sV-CAM-1)含量变化,探讨临床意义。方法采用双抗夹心酶联免疫吸附法(ELISA)测定血清中sICAM-1、sVCAM-1含量。结果脑出血患者sICAM-1、sVCAM-1含量第1d开始升高,与对照组比较差异无统计学意义(P>0.05);第3d、7d含量显著升高,与对照组相比差异有统计学意义(P<0.01);第14d含量开始下降,与对照组相比差异有统计学意义(P<0.01);重型脑出血组与轻型脑出血组比较,第3d、7d差异均有统计学意义(P<0.05,P<0.01)。结论ICAM-1、VCAM-1参与脑血肿周围脑组织炎症反应及继发性脑组织损伤。
Objective To investigate the serum level of slCAM-1, sVCAM-1 in the patients with intracerebral hemorrhage (ICH)and clinical significance. Methods Serum concentration of slCAM-1,sVCAM-1 were determined by ELISA. The stroke patients were assigned to three subgroups according to the Chinese stroke scale: severe group (score 31-45),light group (score 0-15) ,middle group (score 16-30). Results The levels of sICAM-1,sVCAM-1 in the serum of patients with ICH were not remarkbaly higher than that in control group in the first day ( P〉0. 05); The levels of sICAM-1 ,sVCAM-1 in the serum were remarkably higher than that in control group in the third day and seventh day ( P〈0.05, P〈0. 01 ) ; The level was reduced gradually in the fourteenth day , but it was remarkably higher than control group(P〈0.01) ;The levels of sICAM-1, sVCAM-1 in the serum of severe ICH group were remarkably higher than that in light ICH group in the third day and seventh day. Conclusion The ICAM-1, sVCAM-1 are involved in the inflammation in the brain tissue around the hemotoma and secondary brain damage after ICH.
出处
《中国实用神经疾病杂志》
2008年第4期1-4,共4页
Chinese Journal of Practical Nervous Diseases