脑出血患者血清细胞间黏附分子-1与血管细胞黏附分子-1含量变化被引量：5

Study on the change of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the serum of patients with intracerebral hemorrhage

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摘要目的观察脑出血患者1d、3d、7d、14d血清中可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sV-CAM-1)含量变化,探讨临床意义。方法采用双抗夹心酶联免疫吸附法(ELISA)测定血清中sICAM-1、sVCAM-1含量。结果脑出血患者sICAM-1、sVCAM-1含量第1d开始升高,与对照组比较差异无统计学意义(P>0.05);第3d、7d含量显著升高,与对照组相比差异有统计学意义(P<0.01);第14d含量开始下降,与对照组相比差异有统计学意义(P<0.01);重型脑出血组与轻型脑出血组比较,第3d、7d差异均有统计学意义(P<0.05,P<0.01)。结论ICAM-1、VCAM-1参与脑血肿周围脑组织炎症反应及继发性脑组织损伤。 Objective To investigate the serum level of slCAM-1, sVCAM-1 in the patients with intracerebral hemorrhage （ICH）and clinical significance. Methods Serum concentration of slCAM-1,sVCAM-1 were determined by ELISA. The stroke patients were assigned to three subgroups according to the Chinese stroke scale： severe group （score 31-45）,light group （score 0-15） ,middle group （score 16-30）. Results The levels of sICAM-1,sVCAM-1 in the serum of patients with ICH were not remarkbaly higher than that in control group in the first day （ P〉0. 05）; The levels of sICAM-1 ,sVCAM-1 in the serum were remarkably higher than that in control group in the third day and seventh day （ P〈0.05, P〈0. 01 ） ; The level was reduced gradually in the fourteenth day , but it was remarkably higher than control group（P〈0.01） ;The levels of sICAM-1, sVCAM-1 in the serum of severe ICH group were remarkably higher than that in light ICH group in the third day and seventh day. Conclusion The ICAM-1, sVCAM-1 are involved in the inflammation in the brain tissue around the hemotoma and secondary brain damage after ICH.

作者孙伟辉丁美萍卢琦

机构地区浙江湖州市第一医院神经内科浙江大学医学院附属第二医院神经内科浙江湖州市第一医院检验科

出处《中国实用神经疾病杂志》 2008年第4期1-4,共4页 Chinese Journal of Practical Nervous Diseases

关键词脑出血细胞间黏附分子-1 血管细胞黏附分子-1 Cerebral stroke sICAM-1 sVCAM-1

分类号 R743.34 [医药卫生—神经病学与精神病学]

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