CXCL12及受体CXCR4在胆管癌中的表达及其临床意义

Expressions of Chemokine CXCL12 and Its Receptor CXCR4 in Human Cholangiocarcinoma and Their Clinical Significance

目的:探讨趋化因子CXCL12及其受体CXCR4在胆管癌中的表达及与临床病理特征、预后的关系。方法:采用免疫组化SP法检测10例正常胆管、61例胆管癌(19例肝门部胆管癌、42例胆总管中下段癌)组织中CXCL12和CXCR4蛋白的表达。结果:正常胆管中无CXCL12和CXCR4蛋白的表达,胆管癌的CXCL12和CXCR4蛋白的表达分别为88%和53%,有转移的胆管癌中CXCR4蛋白的表达为94%,显著高于无转移组。相关性分析显示CXCR4蛋白的表达与肿瘤是否转移有关,与肿瘤复发时间及存活时间有关。结论:CXCR4可以作为判断胆管癌恶性程度高低及预后的指标之一。

Objective： To explore the expressions of chemokine CXCL12 and its receptor CXCR4 protein in Cholangiocarcinoma and the relationship between clinical pathological features and the prognosis. Methods： The expressions of CXCL12 and CXCR4 protein were detected by immunohistochernistry in 10 cases with normal bile duct and 61 cases with Cholangiocarcinoma. Results： All samples with normal bile duct were negative for CXCL12 and CXCR4 protein expressions and CXCL12 immunopositive rate was 88 % in patients with Cholangiocarcinoma, while CXCR4 was 53%. The intensity of CXCR4 staining had significant relationship with metastatic. In relative analysis, CXCR4 expression was correlated with relative time and survival time. Conclusions： CXCR4 expression is one of potential prognostic factors for Cholangiocarcinoma patients.