摘要
目的:研究特发性便秘患者乙状结肠粘膜内VIP、NOS阳性神经的变化情况。方法:利用免疫组化技术研究了8例特发性便秘患者乙状结肠粘膜内VIP、NOS阳性神经的变化情况并与5例健康人相比较。结果:特发性便秘患者乙状结肠粘膜内NOS阳性神经较正常人明显增多(P<0.01)。结论:特发性便秘的发病可能与结肠内NO产生增多有关。
Objective: To investigate changes of VIP, NOS positive nerves in colon in patients with idiopathic chronic constipation. Methods: We studied 8 ICC patients and 5 controls by immunohistochemistry using anti-VIP and anti-nitric oxide synthase antibodies to evaluate the density of VIP and nitric oxide producing nerves in colonic mucosa. Results: The patients of idiopathic chronic constipation (ICC) showed high density of NO S positive nerve fibers in the colon. Conclusion: The pathogenesis of idiopathic chronic constipation (ICC) may partly be related to the changes of NOS positive nerves in the colon.
出处
《现代生物医学进展》
CAS
2008年第4期679-680,682,共3页
Progress in Modern Biomedicine
基金
湖南省教委科研基金(编号2001-B64)
关键词
便秘
一氧化氮合酶
血管活性肠肽
结肠测压
免疫组化
Constipation
Nitric oxide (NO) synthase
Vasoactive intestinal polypeptide (VIP)
Colonic motility
Immunohistochemistry