替牙期乳牙牙根及牙槽骨吸收过程中RANKL/RANK通路及其调控的研究进展

Progress in Research of RANKL/RANK Pathway and Its Regulation in Root and Alveolar Bone Resorption during the Replacement of Primary and Permanent Teeth

乳恒牙替换是一系列复杂的生理过程。乳牙牙根及牙槽骨吸收是这个过程中的重要环节。以往RANK/RANKL通路研究较多的集中到其对破骨细胞的作用,认为RANK将细胞分化等信号传入破骨细胞前体细胞内,从而诱导破骨细胞的增殖、分化、激活和骨吸收等生物学活性。而RANK/RANKL通路在替牙期乳牙牙根及牙槽骨吸收过程中调控作用的研究特别是对破牙细胞的作用,是近年来研究的热点。本文就乳牙牙根以及牙槽骨吸收过程中RANKL/RANK通路及其调控的研究进展进行了综述;同时介绍了可能参与这一过程的众多细胞因子,它们对这一过程起着正向或负向的调节作用。

Replacement of primary and permanent teeth contains a series of complicated procedures, in which root and alveolar bone resorption is an essential part. In the past, the researches in RANKL/RANK pathway mostly focus on its regulation in osteoclast. It is believed that RANK brings the cellular signals into pre-osteoclasts, in which they induce osteoclasts to generate, differentiate, and activate bone resorption. However, RANKL/RANK pathway and its regulation in root and alveolar resorption, especially in odontoclast, attract more and more scientists＇ interests recently. This review introduces the recent research in RANKL/RANK pathway and its regulation in root and alveolar resorption. Plenty of researches indicate that in root and alveolar resorption, RANKL/RANK pathway may play a similar role in osteoclasts as that in odontoclasts. In addition, varied cytokines possibly involved ha this procedure are also introduced in this review, and they may positively or negatively regulate the root and alveolar resorption.