雌激素治疗绝经妇女压力性尿失禁的临床报告

Clinical Observation of the Effects of Estrogen on Therapy of Menopausal Stress Urinary Incontinence

目的:观察雌激素对绝经妇女压力性尿失禁的疗效。方法:将40例绝经妇女压力性尿失禁患者随机分为实验组和对照组,前者采用雌激素治疗联合盆底肌肉锻炼,后者单纯盆底锻炼。治疗后观察评定尿失禁改善情况,比较分析雌激素的疗效。结果:实验组和对照组总有效率依次为100%和50%,差异具有显著性(P<0.01)。实验组用药后血清促卵泡素水平显著下降,雌激素水平上升至卵泡早期水平,体重、血脂及肝肾功能变化均无统计学意义。结论:雌激素对绝经妇女压力性尿失禁疗效较好,建议临床推广。

Objective： To observe the effects of estrogen on therapy of menopausal stress urinary incontinence. Methods： Forty patients with menopausal stress urinary incontinence were randomly divided into two equal groups. The patients in experiment group were treated with estrogen combined with the exercise of pelvic diaphragm muscle, while the patients in control group were given the exercise of pelvic diaphragm muscle only. The effects of estrogen were compared and analyzed after treatment. Results： The total effective rates were significant differences （P〈0.01） between experiment and control group with 100 % and 50 % respectively. After estrogen therapy, the level of serum FSH （follicle stimulating hormone） decreased significantly with serum estrogen increasing to early follicle stage level in experiment group and no significant change in body weight, （blood） lipid and function of liver and kidney. Conclusions： Estrogen therapy is effective for menopausal stress urinary incontinence.