特发性血小板减少性紫癜的脾切除治疗

Splenectomy for idiopathic thrombocytopenic purpura

目的探讨脾切除对特发性血小板减少性紫癜(ITP)的治疗效果。方法观察近10年间经激素等治疗无效或有应用激素禁忌的27例ITP的脾切除手术治疗,回顾其临床疗效。术后随访1年者22例,随访2年者5例。结果术后3周内血小板恢复正常(≥100×109/L)者23例,后2个月内恢复正常者2例,2例复发。结论经激素治疗无效或有应用激素禁忌ITP,脾切除治疗有效。术后复发者对激素仍然有效。

Objective To investigate the role of nuclear factor κB （NF-κB） in the induction of MMP-3 protein by TNF-α in colon cancer cells and the effect of antioxidant on the induction of MMP-3.Methods ELISA was used to detect the concentrations of MMP-3,NF-κB in the cell nuclei was detected with electrophoretic mobility shift assay.Results MMP-3 protein expression induced by TNF-α was blocked by pyrrolidine dithiocarbamate （PDTC）.TNF-α triggered the activation and translocation of NF-κB and PDTC inhibited the activation of NF-κB induced by TNF-α.Conclusions The induction of MMP-3 protein by TNF-α is dependent on the activation of NF-κB.Antioxidants may inhibit the induction of MMP-3 protein through the inhibition of NF-κB activation.