脂联素与动脉粥样硬化研究的进展

Progress of Research on Association between Adiponectin and Atherosclerosis

脂肪细胞因子是心血管并发症的重要调节因子。其中,脂联素是脂肪细胞分泌的重要血管保护因子。肥胖、糖尿病及冠心痛患者脂联素水平显著降低,低脂联素血症是动脉粥样硬化发生发展的独立危险因素。脂联素既可直接抑制动脉粥样硬化灶的形成,亦可通过间接作用抑制动脉粥样硬化的形成。脂联素在动脉粥样硬化的防治方面有明显的应用前景。

Recently, the research shows that adipose cytokines are the important regulatory factors of the complications of the heart and the blood vessel disease, Among the cytokines, the adiponectin is the important protective factor for blood vessels. The serum adiponectin level is evidently lower in the obese patients and the patients with diabetes mellitus or coronary heart disease. Low serum adiponectin level is an independent risk factor for the development of atherosclerosis. The adiponectin regresses the form of the atherosclerosis focus not only directly but also indirectly. It is very important for the prevention and treatment of atherosclerosis to make use of the adiponectin,