埃索美拉唑与莫沙必利联用治疗胃食管反流病疗效观察

Esomeprazole and Mosapride in the Treatment of Gastroesophageal Reflux Disease

目的:探讨埃索美拉唑与莫沙必利联用治疗胃食管反流病(GERD)的疗效。方法:60例GERD患者,采用随机双盲法分成两组,治疗组30例,给予埃索美拉唑40mg/d,莫沙必利5mg,3次/d,口服。对照组30例,给予法莫替丁20mg,2次/d,莫沙必利5mg,3次/d,口服,于治疗后2、4、6周观察胃烧心、反流、反酸、非心源性胸痛等症状的缓解情况,并于6周后复查胃镜,观察食管炎治愈率。结果:治疗组治疗2、4、6周后总有效率分别为80.00%,86.67%,96.67%,对照组治疗2、4、6周后总有效率分别为53.33%,63.33%,66.67%,两组比较有极显著性差异(P<0.01);治疗组治疗6周后内镜下A、B、C-D级食管炎治愈率分别达92.86%,84.61%,66.70%,对照组治疗6周后内镜下A、B级食管炎治愈率分别为40.00%,30.77%,C-D级食管炎治愈率为零,两组比较有极显著性差异(P<0.01)。结论:埃索美拉唑与莫沙必利联用是治疗胃食管反流病的有效方案。

Objective： To investigate esomeprazole and Mosapride in the treatment of gastroesophageal reflux disease （ GERD） effect. Method： 60 cases of patients with GERD, a randomized double - blind method is divided into two groups, the treatment group of 30 patients given esomeprazole 40 mg/ day, Mosapride 5 rag, 3 times a day, orally. Control group of 30 patients given famotidine 20 rag, twice a day, Mosapride 5 mg, 3 times a day, oral, 2,4,6 weeks after treatment observation stomach heartburn, reflux, and anti - acid, non - cardiac chest pain and other symptoms of mitigation, and in the six weeks after the review gastroscopy, observation esophagitis cure rate. Result： The treatment 2,4,6 weeks after total efficiency were 80.00%, 86.67%, 96.67% , the control group 2,4,6 weeks after total efficiency were 53.33%, 63. 33%, 66.67%, Comparison of the two groups is very significant difference （ P 〈 0.01 ） in the treatment group within six weeks after the endoscopic A, B, CD -esophagitis cure rates were up 92.68%, 84.61% ,Esomeprazole and Mosapride in the Treatment of Gastroesophageal Reflux Disease66.7%, the control group for 6 weeks after endoscopic A, B esophagitis cure rates were 50.00%, 30. 77%, CD-esophagitis cure rate of zero, the two groups are significantly different （ P 〈 0.01 ）. Conclusion ： Esomeprazole and Mosapride combined with the treatment of gastroesophageal reflux disease is effective programmes.