氦-氧机械通气对动物急性肺损伤模型组织形态的影响

Effects of Helium-oxygen Mechanical Ventilation on Histomorphology in ALI Animal Models

目的探讨氦-氧机械通气对动物急性肺损伤(ALI)组织形态的影响。方法应用大鼠脓毒症性急性肺损伤模型,分别用空-氧混合气和氦-氧混合气(Heliox)进行机械通气,观察肺组织形态的差别。结果氦-氧机械通气对动物急性肺损伤模型的肺组织形态学变化未能产生影响。结论氦-氧机械通气不能改善动物急性肺损伤的组织形态,对动物急性肺损伤没有保护作用。

Objective To investigate the effect of Helium - oxygen mechanical ventilation on histomorphology in acute lung injury （ALl） animal models. Methods To investigate the changes of histomorphology in ALl rat models caused by sepsis by comparing air - oxygen mixture mechanical ventilation with helium -oxygen mixture mechanical ventilation. Results Helium -oxygen mechanical ventilation has no influence on the change of lung histomorphology. Conclusion Helium - oxygen mixture mechanical ventilation could not im- prove lung histomorphology. Helium -oxygen mixture mechanical ventilation has no protective effect on ALl animal models.