Fas/Fas-L在乳腺癌与转移淋巴结中的表达及其相互关系

Fas/Fas-L expression in human breast cancer and lymph node metastasis and their correlation

目的探讨Fas/Fas-L在乳腺癌中的表达及其与淋巴结转移的关系。方法采用S-P免疫组化方法对100例乳腺癌组织进行Fas/Fas-L的检测。结果共检测100例乳腺癌,在50例有转移的的乳腺癌中,25例Fas抗体呈阳性反应(50.0%),其中强阳性4例;40例Fas-L抗体呈阳性反应(80.0%),其中强阳性7例。50例中有浸润性导管癌46例,23例Fas抗体呈阳性反应(50.0%),其中强阳性4例;37例Fas-L抗体呈阳性反应(80.4%),其中强阳性6例;有浸润性小叶癌4例,2例Fas抗体呈阳性反应(50.0%),无强阳性,3例Fas-L抗体呈阳性反应(75.0%),其中强阳性1例。在50例无转移的乳腺癌中,22例Fas抗体呈阳性反应(44.0%),其中强阳性2例;22例Fas-L抗体呈阳性反应(44.0%),其中强阳性4例。无转移病例中浸润性导管癌45例,20例Fas抗体呈阳性反应(44.4%),其中强阳性3例,20例Fas-L抗体呈阳性反应(44.4%),其中强阳性4例;有浸润性小叶癌5例,Fas抗体2例呈阳性反应(40.0%),无强阳性,Fas-L抗体2例呈阳性反应(40.0%),无强阳性。乳腺癌的Fas表达与有无淋巴结转移无显著相关(P>0.05),与乳腺癌组织学分类无关(P>0.05);乳腺癌的Fas-L表达与有无淋巴结转移有显著相关性(P<0.05),亦与乳腺癌组织学分类无关(P>0.05)。结论乳腺癌中Fas-L的表达可能与肿瘤逃避免疫监视有关。

Objective To study the association between Fas/Fas-L expression in breast cancer and lymph node metastasis. Methods The S-P immunohistochemical method was used to detect the expression of Fas/Fas-L in tissues of 100 breast cancers and lymph node metastasis. Results Fas expression was detected in 47 （47.0%）breast cancers. There was no difference between those with lymph node metastasis （50.0%） and those without lymph node metastasis （ 44. 0% ） （ P 〉 0. 05 ）. Fas-L expression was detected in 62 （62.0%） breast cancers, there was significant difference between those with lymph node metastasis （80.0%） and those without lymph node metastasis （44.0%） （P 〈 0.05 ）. Conclusion Breast cancer expresses Fas-L and Fas-L may play an important role in the metastasis of breast cancer.