1Gregoretti IV, Lee YM, Goodson HW. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis[J]. J Mol Biol, 2004,338:17-31.
2Grozinger CM, Schreiber SL. Deacetylase enzymes: biological functions and the use of small-molecule inhibitor of histone deacetylase 6 ( HDAC6 )-mediated tubulin deacetylation [ J ]. Chem Biol, 2002,9:3-16.
3Johnstone RW, Licht JD. Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target[J]?Cancer Cell, 2003,4:13-18.
4Melnick A, Licht JD. Histone deacetylases as therapeutic targets in hematologic malignancies [ J ]. Curr Opin Hemat ,2002,9:322-332.
5Kamitanil H, Taniura S, Watanabe K, et al. Histone acetylation may suppress human glioma cell proliferation when p21WAF/ Cipl and gelsolin are induced[J]. Neuro-oncol, 2002, 4(2) : 95-101.
6Li XN, Shu Q, Su JMF, et al. Valproic acid induces growth arrest,apoptosis, and senescence in meduUoblastomas by increasing histone hyperacetylfion and regulating expression of P21Cip1, CDK4, and CMYC [ J ]. Mol Cancer Ther ,2005,4 (12) : 1912-1922.
7Van int C, Emitiani S, Verdin E. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation[J]. Gene Expr, 1996,5:245-253.
8Lavelle D, Chen YH, Hankewych M, et al. Histone deacetylase inhibitors increase P21 ( WAF1 ) and induce apoptosis of human myeloma cell lines in dependent of decreased IL-6 receptor expression[ J]. Am J Hematol, 2001, 68 : 170-178.
9Rosato RR, Almenara JA, Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactire oxygen species and induction of P21CIP1/WAF1 [J]. Cancer Res, 2003,63:3637-3645.
10Sasakawa Y, Naoe Y, Noto T, et al. Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors[ J ]. Biochem Pharmacol, 2003, 66(6) :897-906.
