摘要
通过收集经S-PVP免疫化疗及PVP化疗的口腔鳞癌原发灶内的肿瘤浸润淋巴细胞,计算其每克肿瘤组织中TIL得率;以Tca8113为靶细胞,测定TIL体外的杀癌活性。结果为S-PVP治疗者,每克肿瘤组织中TIL细胞数为7.5×105;PVP治疗者则为2.45×105;前者TIL的得率是后者的3倍。当放靶比为5:1时,S-PVP组TIL的杀后活性为38%,PVP组为32%,两者无显著性差异(P>0.05)。结果提示,S-PVP方案治疗口腔鳞癌,除了化疗药物对肿瘤细胞的直接杀伤,还存在通过生物反应调节剂增加了TIL的数量而达到免疫抗癌作用。
Tumor-infiltrating 1yTnphocyte (TIL) in the primary site of oral SCC treatedwith S-PVP or PVP therapy was collected respectively and its vield,that is calculating theamount of TIL per gram of tumor tissue- The cytotoxicity of TIL against the target,Tca81l3was detected. The results showed that the vield of TIL in S-PVP group was three times overthat in PVP group. At the ratio of 5 to 1 (effector to target) the cytotoxicity was 38% in S-PVP group and 32% in PVP group. There was no significant difference in its cytotoxicity be-tween two groups. The re8ult8 revealed that immunpcjemotherapy of S- PVP regimen fortreating oral SCC had neither direct damage to tumor ce1l from the agents nor antitumor immune reactivity with BRM stimulating an increasing in numbers of TIL.
出处
《上海口腔医学》
CAS
CSCD
1997年第3期151-153,共3页
Shanghai Journal of Stomatology