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牙龈卟啉单胞菌膜泡对牙龈上皮细胞MMPs基因表达的影响 被引量：1

Effects of Porphyromonas gingivalis vesicles on MMPs gene expression of gingival epithelial cells.
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摘要 目的:探讨牙龈卟啉单胞菌膜泡对牙龈上皮细胞基质金属蛋白酶(MMPs)基因表达的影响,揭示牙龈卟啉单胞菌在牙周炎中的致病作用。方法:以Real-timeRT-PCR法检测牙龈卟啉单胞菌膜泡刺激下牙龈上皮细胞MMP-1和MMP-3的mRNA表达水平。结果:牙龈卟啉单胞菌膜泡显著地上调MMP-1和MMP-3mRNA表达水平。结论:牙龈卟啉单胞菌诱导牙龈上皮细胞发生细胞炎症反应,可能是牙周炎发生、发展的重要因素。 Objective：To study the effects of Porphyromonas gingivalis vesicles on matrix metalloproteinases（MMPs） gene expression of gingival epithelial cells and the pathogenesis of Porphyromonas gingivalis in periodontitis. Method：The effects of Porphyromonas gingivalis vesicles on MMP-1 and MMP-3 mRNA expression of gingival epithelial cells were determined by Real-time RT-PCR. Resulut：Porphyromonas gingivalis vesicles significantly up-regulated MMP-1 and MMP-3 mRNA expression of gingival epithelial cells. Conclusion：Cellular inflammatory responses of gingival epithelial cells induced by Porphyromonas gingivalis may contribute to the initiation and progression of periodontitis.
作者 寇育荣 潘亚萍
机构地区 中国医科大学口腔医学院口腔内科
出处 《临床口腔医学杂志》 2008年第3期140-142,共3页 Journal of Clinical Stomatology
基金 辽宁省教育厅高等学校科学研究项目计划(202013154)
关键词 牙龈卟啉单胞菌 牙龈上皮细胞 基质金属蛋白酶 Porphyromonas gingivalis gingival epithelial cell matrix metalloproteinases（MMPs）
分类号 R780.2 [医药卫生—口腔医学]
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参考文献9

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同被引文献32

  • 1寇育荣,潘亚萍.牙龈卟啉单胞菌膜泡诱导牙龈上皮细胞炎性反应的体外研究[J].中华口腔医学杂志,2007,42(9):564-567. 被引量：3
  • 2Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponemadenticola, and Tannerella forsythia: the "red complex", a proto- type polybacterial pathogenic consortium in periodontitis [J]. Periodontol 2000, 2005, 38: 72-122.
  • 3Tokutomi F, Wada-Takahashi S, Sugiyama S, et al. Porphy- romonas gingivalis-induced alveolar bone loss is accelerated in the stroke-prone spontaneously hypertensive rat [J]. Arch Oral Biol, 2015, 60(6):911-918.
  • 4Slots J, Bragd L, Wikstrtom M, et al. The occurrence of Actino- bacillus actinomycetemcomitans, Bacteroides giugivalis and Bac- teroides intermedius in destructive periodontal disease in adults [J]. J Clin Periodontol, 1986, 13(6) : 570-577.
  • 5Nakagawa T, Yamada S, Tsunoda M, et al. Clinical, microbio- logical, and immunological studies following initial preparation in adult periodontitis [J]. Bull Tokyo Dent Coil, 1990, 31 (4) : 321-331.
  • 6Grenier D, Mayrand D. Selected characteristics of pathogenic and nonpathogenic strains of Bacteroides gingivalis [J]. J Clin Microbial, 1987, 25(4): 738-740.
  • 7van Winkelhoff AJ, Appelmelk BJ, Kippuw N, et al. K-anti- gens in Porphyromonas gingivalis are associated with viru- lence [J]. Oral Microbiol Immunol, 1993, 8(5) : 259-265.
  • 8Nakagawa I, Amano A, Kuboniwa M, et al. Functional differ- ences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial ceils [J]. Infect Immun, 2002, 70(1 ): 277-285.
  • 9Hanazawa S, Murakami Y, I-Iirose K, et al. Bacteroides (Por- phyromonas) gingivalis fimbriae activate mouse peritoneal mac- rophages and induce gene expression and production of interleu- kin-1 [J]. Infect Immun, 1991, 59(6) : 1972- 1977.
  • 10Nakagawa I, Amano A, Kimura RK, et al. Distribution and mo- lecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene [J]. J Clin Microbiol, 2000, 38 (5) : 1909-1914.

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临床口腔医学杂志
2008年 第3期

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