期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Tubedown-1与视网膜新生血管

原文传递
导出
摘要 组蛋白乙酰化与去乙酰化对于基因转录具有重要的调控作用，乙酰化水平由组蛋白乙酰转移酶（Histone acytyltransferase HATs）和组蛋白去乙酰化酶（Histone deacytylases HDACs）共同调控。Tubedown-1是一种新发现的N-末端乙酰转移酶。研究表明，其对眼部脉管系统发育及缺氧状态下视网膜新生血管形成及发展有调控及抑制作用。为此综述了组蛋白乙酰化与基因转录及视网膜新生血管的关系，介绍针对这一新的酵母菌乙酰转移酶同源基因的研究成果。
作者 吴海星 张学东
机构地区 重庆医科大学附属第一医院眼科
出处 《中国实用眼科杂志》 CSCD 北大核心 2008年第2期97-100,共4页 Chinese Journal of Practical Ophthalmology
关键词 组蛋白乙酰化 乙酰转移酶 视网膜新生血管 Tubedown-1
分类号 R988.1 [医药卫生—药品] R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1Driessen H P, de Jong W, Tesser G I, Bloemendal H, The mechanism of N-terminal acetylation of proteins. CRC Cru Rev Biochem,1985,18(4):281-325.
  • 2Vigushin D M, Coombes R C, Targeted histone deacetylase inhibi- tion for cancer therapy[J] o Current Cancer Drug Targets, 2004,4 (2):205-218.
  • 3Bownell J E, Allis C D. Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation. Curt Opin Genet Dev, 1996,6(2): 176-184.
  • 4Ruiz-Carrillo A, Aangh L J, Allfrey V G. Processing of newly synthesized histone molecules. Science, 1975,190(4210): 117-128.
  • 5Sterner D E, Berger S L. Acetylation of histones and transcription-related factors. Microbiology and Molecular Biology Reviews, 2000, 64(2):435-459.
  • 6Gray G C4 Ekstrom T J. The human histone deacetylase family[J]. Exp Cell Res, 2001,262:75-83.
  • 7Zhou X, Marks R A, Rifkind R A ,et al. Cloning and characteriza- tion of a histone deacetylase,HDAC9[J].Proc Natl Acad Sci,2001, 19:10572-10577.
  • 8Landry J. The silencing protein SIR2and its homoibgs are NAD- dependant protein deacetylases[J].Proc Natl Acad Sci,2000,97:5807- 5811.
  • 9Allfrey V G. Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis[J].Proc Can Cancer Conf, 1966,6:313-335.
  • 10Min J H ,Yang H, Ivan M, et al. Structure of an HIF-1 alph-PVHL Complex: hydroxyproline recognition in signaling. Science, 2002, 296(5574): 1886-1889.

二级参考文献32

  • 1黎晓新.我国早产儿视网膜病变特点和筛查指南[J].中华眼底病杂志,2004,20(6):384-386. 被引量：140
  • 2Ward RM, Beachy JC. Neonatal complications following preterm birth. Br J Obstet Gynaecol,2003, 110 (Suppl 20) :8-16.
  • 3The Royal College of Ophthalmologist and the British Association of Perinatal Medicine. Retinopathy of prematurity: guidelines for screening and treatment. The report of a Joint Working Party of Early Human Development, 1996,46:239-258.
  • 4An international classification of retinopathy of prematurity.Prepared by an international committee. Br J Ophthalmol, 1984,68:690-697.
  • 5Cryotherapy for Retinopathy of Prematurity Cooperative group.Multicenter trial of cryotherapy for retinopathy of prematurity:preliminary results. Arch Ophthalmol, 1988,106:471-479.
  • 6Subhani M, Combs A, Weber P, et al. Screening guidelines for retinopathy of prematurity: The need for revision in extremely low birth weight infants. Pediatrics ,2001,107:656-659.
  • 7Multicenter trial of cryotherapy for retinopathy of prematurity.Preliminary result. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthalmol, 1988,106 : 471-479.
  • 8Gariano RF. Cellular mechanisms in retinal vascular development.Progress in Retinal and Eye Research, 2003, 22: 295-306.
  • 9Palmer EA, Flynn JT, Hardy RJ, et al. Incidence and early course of retinopathy of prematurity. Ophthalmololgy,1991, 98:1628-1640.
  • 10Haines L, Fielder AR, Pollock JI, et al. Retinopathy of prematurity in the UK. I: the organization of services for screening and treatment. Eye, 2002,16 : 33-38.

共引文献29

中国实用眼科杂志
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部