利胆化瘀片提取工艺研究

Studies on the Extraction Process of Lidanhuyu Tablets

目的：筛选利胆化瘀片的最佳水煎提取工艺。方法：以出膏量及槲皮素和山柰素总量作为考察指标，采用L9（3^4）正交表进行筛选，考察了加水量、煎煮时间、煎煮次数等因素以确定最佳的提取工艺。结果：煎煮次数对提取效果的影响最明显，最佳工艺为加10倍水量、每次煎煮1．5h、煎煮3次。结论：该试验所优选的工艺稳定、可靠，可用于实际生产制备。

Objective： TO optimize the extraction process and condition of Lidanhuyu tablets. Method： The factors of affecting extraction of effective ingredients including the added amount of water, the extracting time and times of extraction were studied by L9 （3^4 ） orthogonal design with the yield of dry extract and the total count of quercitrin and kaempferol were observed as the indicator. Result： The times of extraction were the most significant factor, and the optimal extraction process and condition of Lidanhuyu tablets were 3 times extraction, 1.5 h for extraction process and 10 times amount of water. Conclusion： The experiment results showed that the extraction process and condition were stable and reliable.