单次和连续口服地芬尼多对实验室指标的影响

Effect of laboratory indexes by taking diphenidol single or continuous

目的:评价单次和连续口服地芬尼多对实验室指标的影响。方法:12名健康志愿者,单次口服地芬尼多片,于试验前、后分别测定其实验室指标;另12名健康志愿者,连续口服地芬尼多片6d,于试验前、中、后分别测定实验室指标。结果:单次口服地芬尼多可以导致血Na、TG升高和CK、TC、HR降低;连续口服地芬尼多可以导致血Na、Cr升高,CK、K、HR降低和QT间期延长。结论:口服地芬尼多可以引起相关实验室指标的改变。

Objective： To evaluate the effect of laboratory indexes by taking diphenidol single and continuous. Method： Twelve volunteers were orally given diphenidol tablets singly. Laboratory indexes were determined before and after trial period respectively. Other 12 volunteers were orally given diphenidol tablets continuous lasting 6 days. Laboratory indexes were determined before, inter and after trial period respectively. Result： orally given diphenidol singly lead to Na,TG raise and CK, TC, HR decrease; Orally given diphenidol continuous lead to Na, Cr raise; CK, K, HR decrease and prolong QT period. Conclusion： Orally given diphenidol tablets can change some relevant laboratory indexes