C57BL/6小鼠晚期Lewis肺腺癌化疗疗效评价

Assessment of the use of paclitaxel and cisplatin in advanced Lewis lung carcinoma in C57BL/6 mice

目的评价化疗对晚期非小细胞肺癌生存期的影响。方法建立C57BL/6小鼠晚期肺癌模型,实验组采用临床常用的紫杉醇/顺铂联合化疗方案,对照组给予等量生理盐水,观察两组小鼠的生存期、精神状态及体质量变化。结果实验组较对照组能延长小鼠的生存期,差异有显著性(P<0.01);实验组精神状态评分高于对照组,差异有显著性(P<0.01);两组小鼠体质量降低程度差异无显著性(P>0.05)。结论对于一般状态较好的C57BL/6小鼠晚期非小细胞肺癌,紫杉醇/顺铂联合化疗能延长其生存期,改善生存质量。

Objective To assess the utility of paclitaxel and cisplatin to increase the survival time of C57BL/6 mice with advanced nonsmall cell lung cancer （NSCLC）. Methods Advanced lung cancer model was established in C57BL/6 mice. One group was treated with the standard therapeutic regimen of paclitaxel and cisplatin. The control group was injected only with 0.9% isotonic NaCl. Survival time, mental state and weight of each group were recorded. Results The survival time of the experimental group was significantly greater than the control group （ P 〈 0.01 ）. The two groups were not significantly different in weight loss （ P 〉 0.05 ） and the experimental group had significantly better mental score index than the control group （ P 〈 0.01 ）. Conclusion The combination of paclitaxel and ciplatin can prolong the survival time and improve quality of life of mice with advanced NSCLC.