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吲哚胺2，3双加氧酶在病毒感染中的作用 被引量：1

Function of indoleamine 2,3-dioxygenase in viral infection
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摘要 吲哚胺2,3双加氧酶(indoleamine 2,3-dioxy- genase,IDO)是色氨酸犬尿氨酸代谢途径的限速酶.IDO在抗病毒免疫中起重要作用,他能介导IFN-γ抗病毒及有免疫调节和致免疫耐受功能.本文就其在抗病毒免疫方面作一综述. The enzyme indoleamine 2, 3-dioxygenase （IDO）, which catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan degradation, plays a key role in the antiviral immune. IDO mediates IFN-γ antivirus and serves immunoregulatory and tolerogenic functions. In this review, we introduce the studies on the antiviral immune of IDO in viral infection.
作者 曾道炳 卢实春
机构地区 首都医科大学附属北京佑安医院肝胆外科
出处 《世界华人消化杂志》 CAS 北大核心 2008年第8期879-884,共6页 World Chinese Journal of Digestology
基金 国家自然科学基金 No.30671977 首都医科发展科研基金 No.2005-2034~~
关键词 吲哚胺2 3双加氧酶/IDO 病毒 免疫 Indoleamine 2, Immune 3-dioxygenase Virus
分类号 R965 [医药卫生—药理学] R512.62 [医药卫生—内科学]
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参考文献51

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  • 5Williams LM,Rudensky AY.Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.Nat Immunol.2007;8(3):277-284.
  • 6Tesniere A,Panaretakis T,Kepp O,Apetoh L,Ghiringhelli F,Zitvogel L,Kroemer G.Molecular characteristics of immunogenic cancer cell death.Cell Death Differ.《 2008;15(1):3-12.
  • 7Rescigno M,Avogadri F,Curigliano G.Challenges and prospects of immunotherapy as cancer treatment.Biochim Biophys Aeta.2007;1776(1):108-123.
  • 8McKee MD,Roszkowski JJ,Nishimura MI.T cell avidity and tumor recognition:implications and therapeutic strategies.J Transl Med.2005;3:35.
  • 9June CH.Adoptive T cell therapy for cancer in the clinic.J Clin Invest.2007;117(6):1466-1476.
  • 10June CH.Principles of adoptive T cell cancer therapy.J Clln In vest.2007;117(5):1204-1212.

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世界华人消化杂志
2008年 第8期

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