摘要
Foxp3^+调节性T细胞在调控免疫病理、防止机体遭受免疫损伤中起到重要作用.在肠道,初始T细胞受到抗原激活后表达Foxp3,这一过程需要维甲酸和转移生长因子(TGF-β)的参与.维甲酸是肠道相关树突状细胞产生的维生素A的代谢产物,通过诱导T细胞产生整合素α_4β_7和CCR_9,提高外周天然T细胞转化为调节性T细胞的能力,并使其定居肠道.此外维甲酸还可以减少RORγt,来降低Th17、提高调节性T细胞的转化.
FOXP3^＋ regulatory T cells play a key role in controlling immune pathological reactions and preventing organs from immune damages. In the gut, native T cells express FOXP3 when antigens make T cells active, It is necessary for the retinoic acid and transforming growth factor β（TGF-β） to involve in the procession. The retinoic acid is the metabolite of vitamin A produced by gut-associated dendritic cells, with induction T cells to produce integrin α4β7 and CCR9, which enhance the ability in transferring native T cells into regulatory T cells, and regulatory T cells migrate preferentially to the small intestine, Besides, retinoic acid can make RORγt weak, resulting in the reduction of Th17 and the improvement of regulatory T cell transformation.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第8期885-891,共7页
World Chinese Journal of Digestology
