经典Wnt信号通路与肝脏关系的研究进展

Advances in the relationship between canonical Wnt pathway and liver

经典Wnt信号转导通路的暂时激活在肝脏发育、出生后肝脏正常生长、肝细胞再生、肝小叶分带、肝脏代谢和氧化应激反应过程中发挥着重要作用,研究显示这条通路异常持续激活与多种慢性肝病的进展显著相关.近年来针对经典的Wnt信号通路在肝脏病理生理过程中的作用作了大量的研究,并取得一些进展,本文对此作一综述.

A number of studies have demonstrated the important roles of canonical Wnt pathway in the essential physiologic processes in liver, such as development, growth, regeneration, zonation, metabolism, and oxidative stress. Likewise, there have been advances have been made in understanding the role of β-catenin in the development of various liver diseases. Studies of pathological specimens and rodent models of liver diseases have demonstrated aberrations in the canonical Wnt pathway in conditions ranging from hepatitis to hepatocellular carcinoma （HCC）. In this article, we review the above roles of canonical Wnt pathway in liver health and diseases.