肝肾综合征肾血管收缩机制的研究进展

Research progress in the mechanism of renal vasoconstriction in hepatorenal syndrome

肝肾综合征(hepatorenal syndrome,HRS)是肝病晚期并发的肾功衰竭综合征,肾脏本身无器质性病变,肾血管收缩是其病理生理标志.目前肾血管收缩的可能机制为肾脏神经体液系统激活,肾血管活性物质失衡,引起肾血管收缩的细胞内分子信息传递机制.本文就其相关研究进展进行综述.

Hepatorenal syndrome （HRS） is defined as the development of renal failure in patients with severe liver disease in the absence of any other identifiable cause of renal pathology. The hallmark of HRS is renal vasoconstriction. The cause of renal vasoconstriction may involve several factors： activation of renal nervous system, imbalance of renal vasoactive mediators and molecular mechanism. In this review, we summarize the above progress.