基质细胞衍生因子1对骨髓间充质干细胞的趋化作用

Chemotaxis of stromal celldirived factor-1 on bone marrow mesenchymal stem cells

骨髓干细胞主要由造血干细胞和间充质干细胞组成,其中骨髓间充质干细胞除具有自我更新和多向分化的潜能外,更具有很强的可塑性,在一定的诱导条件下能向多细胞分化,且其相对容易获得,成为近年来研究的热点.许多体内外试验证实,细胞因子可以影响移植细胞的微环境,进而影响骨髓干细胞的动员、迁移及分化.基质细胞衍生因子1是一类对免疫细胞有趋化作用的小分子蛋白,属于CXC趋化因子之一,具有广泛的生物学活性,对骨髓干细胞亦有趋化作用,现就SDF-1对骨髓间充质干细胞的趋化作用作一综述.

Bone marrow stem cells （BMC） mainly include hematopoietic stem cells （HSC） and mesenchymal stem cells （MSC）. MSC not only have the potential capability of self-renewal and multi-directional differentiation, but also have a higher plasticity to differentiate into a variety of cells under the specific conditions. In addition, MSC can be easily obtained, and have been extensively studied in recent years. Many studies in vivo and in vitro have confirmed that some cytokines can influence the microenvironment of transplanted cells, resulting in the mobilization, migration and differentiation of BMC. Stromal cell-derived factor-1 （SDF-1） is a CXC-type chemokine with a wide biological activity, and it also has chemotaxis effect on BMC, which is reviewed in this article.