4-芳基-2-(2-羟苄亚氨基)噻唑类化合物的合成与杀菌活性

Synthesis and Fungicidal Activity of 4-Aryl-2-Benzyliminothiazole

以α-溴芳基酮与硫脲反应环合得4-芳基-2-氨基噻唑,4-芳基-2-氨基噻唑与水杨醛反应制备了9种4-芳基-2-(2-羟苄亚氨基)噻唑类化合物.新化合物结构经1HNMR确证.初步的杀菌活性测定结果表明:在500mg/L的试验浓度下,化合物(E)-4-(3-三氟甲基苯)-2-(2-羟苄亚氨基)噻唑对水稻纹枯病菌的抑制率为60.0%,化合物(E)-4-(2-氯-4-(4-氯苄基)苯)-2-(2-羟苄亚氨基)噻唑和(E)-4-(3-氯苯)-2-(2-羟苄亚氨基)-5-甲基噻唑对油菜菌核病菌的抑制率分别为65.4%和56.1%.

4-arylthiazol-2-amines were synthesized by the reaction of a-bromoarylalkyl ketone with thiourea, and further reacted with salicylal to give nine 4-aryl-2-benzyliminothiazoles. The structures of all new compounds were confirmed by ^1HNMR spectra. The results of preliminary bioassay show that the title compound （E）-2-（（4-（3-（triiquoromethyl） phenyl） thiazol-2-ylimino）methyl） phenol exhibits an inhibition rate of 60.0 % against Rhizoctonia solani at a concentration of 500 mg/L and that the inhibition rates of compounds （E）-1-（2-chloro-4-（4-chlorophe-noxy）phenyl）-2-（2-（2-hydroxybenzylideneamino） thiazol-4-yl） ethanone and （E）-2-（（4-（3-chlorophenyl） thiazol-2-ylimino） methyl） phenol against Sclerotinia sclerotiorum are 65.4% and 56.1%, respectively.