摘要
以α-溴芳基酮与硫脲反应环合得4-芳基-2-氨基噻唑,4-芳基-2-氨基噻唑与水杨醛反应制备了9种4-芳基-2-(2-羟苄亚氨基)噻唑类化合物.新化合物结构经1HNMR确证.初步的杀菌活性测定结果表明:在500mg/L的试验浓度下,化合物(E)-4-(3-三氟甲基苯)-2-(2-羟苄亚氨基)噻唑对水稻纹枯病菌的抑制率为60.0%,化合物(E)-4-(2-氯-4-(4-氯苄基)苯)-2-(2-羟苄亚氨基)噻唑和(E)-4-(3-氯苯)-2-(2-羟苄亚氨基)-5-甲基噻唑对油菜菌核病菌的抑制率分别为65.4%和56.1%.
4-arylthiazol-2-amines were synthesized by the reaction of a-bromoarylalkyl ketone with thiourea, and further reacted with salicylal to give nine 4-aryl-2-benzyliminothiazoles. The structures of all new compounds were confirmed by ^1HNMR spectra. The results of preliminary bioassay show that the title compound (E)-2-((4-(3-(triiquoromethyl) phenyl) thiazol-2-ylimino)methyl) phenol exhibits an inhibition rate of 60.0 % against Rhizoctonia solani at a concentration of 500 mg/L and that the inhibition rates of compounds (E)-1-(2-chloro-4-(4-chlorophe-noxy)phenyl)-2-(2-(2-hydroxybenzylideneamino) thiazol-4-yl) ethanone and (E)-2-((4-(3-chlorophenyl) thiazol-2-ylimino) methyl) phenol against Sclerotinia sclerotiorum are 65.4% and 56.1%, respectively.
出处
《华南理工大学学报(自然科学版)》
EI
CAS
CSCD
北大核心
2008年第3期60-63,共4页
Journal of South China University of Technology(Natural Science Edition)
基金
国家科技支撑计划项目(2006BAE01A01-4)