深圳计划生育门诊中男性人乳头状瘤病毒感染状况

Prevalence and distribution of human papillomavirus infection in males of Shenzhen's Family Plan Centre Clinic

目的了解深圳计划生育门诊中男性HPV感染的流行型别和分布状况。方法采用基因分型芯片方法检测23种基因亚型,高危型18种:HPV-16,18,31,33,35,39,45,51,52,53,56,58,59,66,68,73,83,MM4和低危型5种:HPV-6,11,42,43,44。结果112例临床标本中25例阳性,深圳男性HPV检测阳性率是22.3%,最常见的HPV基因亚型是6、16和73型。就诊的男性以31～40岁的年龄组最多,其次是21～30岁年龄组,但发现年龄与男性HPV的感染无相关性。多重HPV感染中,以双重感染33/73型感染最多,高危型和低危型混合感染最常见。结论本次检测可知深圳计划生育门诊中男性HPV最常见的HPV基因亚型是6、16和73型,同时,发现年龄与男性HPV的感染无相关性。

Objective To understand prevalence and distribution of human papillomavirus infection in STD males of Shenzhen＇s Family Plan Centre. Methods 23 genotypes, including 18 high-risk genotypes： HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 83, MM4 and 5 low-risk genotypes： HPV-6, 11, 42, 43, 44 were tested with DNA Chip in patient. Results All of 112 clinic samples, 25 were found to be HPV positive, positive rate was 22.3%, including high-risk genotypes： HPV-16, 18, 33, 35, 56 and 73, and low-risk genotypes： HPV-6, 11, 43. The most common genotype were HPV-6, 16 and 73. Ages of male patients were mostly ranged from 31 years old to 40 years old and next ones were 21-30 years old, there was no relationship between age and HPV infection. In multiple infections, 33/73 of double infections were the most. Meanwhile, mixed infections with high-risk genotypes and low-risk genotypes were most prevalent in all coinfections. Conclusion Through the detection, we can find the most common genotype were HPV-6, 16 and 73 in males of Shenzhen＇s Family Plan Centre Clinic. Meanwhile, age was found not to be relative with HPV infection.