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细胞质膜微囊与信号转导 被引量：2

Plasmalemmal Vesicles (caveolae)and Signal Transduction .
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摘要 细胞质膜微囊 (caveolae)为 50～ 1 0 0nm的小囊泡 ,它们以内陷形式连接在细胞质膜上 ,并广泛存在于各种类型的细胞 .早在 4 0多年前用透射电镜曾观察到此微囊结构 .细胞质膜微囊的功能为通过毛细管内皮细胞转运小分子及大分子以及具有“液饮”作用 .最近实验表明 。 Caveolaeare 5 0～ 1 0 0nmmembrane micro invaginationsassociatedwiththeplasma membraneofavarietyofcells.Theywerefirst identifiedintransmissionelectronmicrographs 40 yearsago.Functionally ,caveolaearethought toparticipateintranscellulartransportofboth smallandlargemoleculesacrosscapillary endothelialcells.Inaddition ,caveolaehavebeen postulatedtofunctionin potocytosis.More recently,thereisgrowingevidencethatcaveolae also participateintransmembranesignal transduction .
作者 黄芬
机构地区 中国科学院生物物理研究所
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 1997年第3期194-198,共5页 Progress In Biochemistry and Biophysics
关键词 细胞学 细胞质膜微囊 微囊蛋白 信号转导 caveolae ,caveolin ,G protein coupling receptor,signaltransduction
分类号 Q73 [生物学—分子生物学]
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同被引文献21

  • 1Zhao Y Y, Liu Y, Stan R V, et al. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci USA, 2002, 99 (17) : 11375- 11380.
  • 2Razani B, Combs T P, Wang X B, et al. Caveolin-l-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem,2002, 277 (10): 8635-8647.
  • 3Razani B, Wang X B, Engelman J A, et al. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol, 2002, 22 (7) : 2329-2344.
  • 4Park D S, Woodman S E, Schubert W, et al. Caveolin-1/3 double-knockout mice are viable, but lack both muscle and nonmuscle eaveolae, and develop a severe cardiomyopathic phenotype.Am J Pathol, 2002, 160 (6): 2207-2217.
  • 5Woodman S E, Park D S, Cohen A W, et al. Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem, 2002,277 (41): 38988-38997.
  • 6Okamoto T, Schlegel A, Scherer P E. Caveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membrane. J Biol Chem, 1998, 273(10) : 5419-5422.
  • 7Engelman J A, Zhang X L, Lisanti M P. Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. FEBS Lett, 1999, 448 (2-3): 221-230.
  • 8Fra A M, Pasqualetto E, Mancini M, et al. Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2. Gene, 2000, 243 (1-2): 75-83.
  • 9Razani B, Altschuler Y, Zhu L, et al. Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virusin a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochemistry,2000, 39 (45): 13916- 13924.
  • 10Bagnoli M, Tomassetti A, Figini M, et al. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly rented to alpha-folate receptor overexpression. Oncogene, 2000, 19(41) : 4754-4763.

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生物化学与生物物理进展
1997年 第3期

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