MRP基因与肿瘤的多药耐药性

MRP Gene and Multidrug Resistance of Cancer

在人肿瘤非典型性多药耐药机制的研究中发现了一个新的基因———多药耐药相关蛋白基因(MRP) .该基因位于人 1 6号染色体P1 3∶3,编码 1 531个氨基酸 .其产物为多药耐药相关蛋白(MRP) ,分子质量 1 90ku ,故又名 p1 90 .MRP属ABC超家族成员 ,主要分布在细胞的质膜上 .MRP的功能可能是在能量依赖的外排系统中发挥作用 .除了一些肿瘤细胞系外 ,MRP基因的高表达还见于一些血液系肿瘤及乳腺癌等 .MRP基因的高表达还可能与某些肿瘤的复发和预后有关 .

A new gene which called multidrug resistant associated protein gene (MRP) was found in the study of the mechanism of multidrug resistance of cancer. The cognate gene is located on chromosome 16 at band P13∶3. Its mRNA encodes a member of the ATP-binding cassette transmemberance transporter superfa- mily with a mass of molecular 190 ku (p190). The MRP is mainly located on the plasma membrane and may play a role in the ATP dependent transport system. Further study indicates that apart from some kind of cancer cell lines, MRP overexpression was found in some blood malignancy, breast cancer, lung cancer and so on. The overexpression may be also related to the relapse of cancer.