摘要
N-甲基-D-门冬氨酸受体（NMDA或NR）功能的变化与癫痫的发生和发展密切相关．本文用原位杂交技术探讨了遗传癫痫易感大鼠P77PMC惊厥后不同时间NRI亚基基因表达状况，证明：大脑皮层，海马齿状回，CA1、CA2、CA3及下丘NR1mRNA表达呈时间依赖性增高，下丘在惊厥后2h即出现NR1mRNA高表，而大脑皮层和海马各区域24h达高峰．听源性惊厥后这些区域NR1mRNA表达的上调可能与神经网络兴奋性增高及癫痫易感性的保持有关。
Change in function of N-methyl-D-aspartate receptor is associated with initiation and development of epilepsy.Here we utilized genetically epilepsy-prone rat(P77PMC) to investigate the changes in NR1 subunit gene expression after audiogenic seizure. The results showed that the expression of NR1 mRNA exhibited time-dependent changes in cerebral cortex, hippocampus, inferior colliculus and reached a peak at 24 hr in cerebra1 cortex, hippocampus, 2 hr in inferior colliculus,respectively, after audiogenic seizures. These findings indicated that audiogenic seizures rnedified NR1 gene expression,which may contribute to an altered excitabi1ity of neuronal network.
出处
《神经解剖学杂志》
CAS
CSCD
北大核心
1997年第1期19-24,共6页
Chinese Journal of Neuroanatomy
基金
国家自然科学基金
