宫颈巴氏涂片与液基细胞薄层技术（TCT）的比较分析

Comparing the conventional papanicolaou smear test with thinPrep cytology test department of obstetrics and gynecology

目的比较宫颈巴氏涂片与液基细胞薄层技术（ThinPrep Cytology Test，TCT）在宫颈病变筛查中的作用。方法使用传统巴氏涂片和TCT同时对309名宫颈病变筛查妇女进行细胞学检查，对两种方法的标本满意度及细胞学检查结果进行比较。结果巴氏涂片标本满意度为94．5％，TCT标本满意度为99．03％，两者有显著性差异（P〈0．05）。阳性病变的检出率传统巴氏涂片为18，77％，（巴氏Ⅲ级及以上）。TCT为20．39％（非典型鳞状上皮或非典型腺上皮以上），两者无统计学差异（P〉0．05）。结论由于采用新的取材、制片方法，在标本满意度上，TCT比传统巴氏涂片有明显改善；在阳性病变的检出率上，TCT比传统巴氏涂片也有所改善；而传统巴氏涂片因具有经济、简便、快捷的优点，在经济落后地区推广有一定意义。可以尝试通过改进巴氏涂片的取材和制片方法，从而提高巴氏涂片的灵敏度和特异度。

Objective To Compare the conventional Papanicolaou smear test with ThinPrep cytology test （TCT） for cervical carcinoma screening. Methods 309 women received both Pap smear and TCT , compared their specimen satisfaction and cytological diagnosis result . Results The specimen satisfaction of Pap smear was 94.5%, while TCT was 99.03%, it increased respectively（P〈0.05）. In the patients with Cervical lesions , the detective rate of Pap smear was 18.77% （they were diagnosed as Bethesda Ⅲ or up） , while that of TCT was 20.39%（they were diagnosed as atypical squamous cells or up）, TCT increased mildly, there was no significance difference（P〉O. 05）. Conclusions Because of new application in drawing material and smear-making, compared with conventional Pap smear, the specimen satisfaction of TCT improves obviously, the detective rate increases mildly. Since Pap smear is much cheaper, speedier and more convenient, it is worthy of popularizing in the backward area in our country. Therefore , we may try to change the means of drawing material and smear-making of Pap smear, so as to improve its sensitivity and specificity.