醋酸地塞米松固体脂质纳米粒的制备及表征

Preparation and Characterization of Dexamethasone Acetate-loaded Solid Lipid Nanoparticles

以山嵛酸甘油酯(Compritol 888 ATO)为载体,采用热融-超声法制备醋酸地塞米松固体脂质纳米粒。制品平均粒径(106.8±6.8)nm,DSC结果表明药物包载在纳米粒中。稳定性初步研究显示纳米粒的外观和包封率在3个月内较稳定。体外释放试验表明,纳米粒在pH7.4磷酸盐缓冲液释药前期有一定量的突释,后期则具有明显的缓释特征,释放时间可达6d。

The solid lipid nanoparticles （SLN） loaded with dexamethasone acetate using Compritol 888 ATO as the matrix were prepared by melting-ultrasonic dispersion technique. The mean diameter was （106.8±6.8）nm. The results of differential scanning calorimetry （DSC） showed that dexamethasone acetate was entrapped in the SLN. The appearance and entrapment efficiency of the products were stable in three months. The in vitro release test showed that the drug could sustained-release from SLN within 6 days in phosphate buffer solution （pH 7.4） after a burst release in initial phase.