摘要
目的通过观察丁丙诺啡、东莨菪碱与异丙嗪三药联合使用（俗称“1＋1”）对大鼠位置偏爱的影响，探索“1＋1”对实验大鼠的精神依赖性潜力。方法161只雄性SD大鼠随机分成9组，分别采用丁丙诺啡、丁丙诺啡＋东莨菪碱、丁丙诺啡＋异丙嗪、丁丙诺啡＋东莨菪碱＋异丙嗪、东莨菪碱、异丙嗪、东莨菪碱＋异丙嗪、吗啡、以及生理盐水等进行腹腔内注射，同时进行药物匹配CPP训练，共10d，比较各组大鼠训练前后以及训练后各组大鼠之间在药物训练侧（简称伴药侧）停留时间的差异，探索各处理因素的精神依赖性潜力及其差异。结果注射吗啡、丁丙诺啡、丁丙诺啡＋东莨菪碱、丁丙诺啡＋异丙嗪、丁丙诺啡＋东莨菪碱＋异丙嗪等5组大鼠均形成了明显的CPP；组间比较发现丁丙诺啡＋东莨菪碱＋异丙嗪组大鼠训练前后在非自然偏爱侧停留时间增加（378．6±120．8）s，明显高于丁丙诺啡组（302．2±133．9）s，差异有显著性（F=62．9，P=0．03），但与吗啡组（419．8±146．4）s比较，差异无显著性（P=14．3，P=0．63）。结论丁丙诺啡、东莨菪碱与异丙嗪之间可能存在协同作用而增加了丁丙诺啡的滥用潜力。
Objective To study the potentiality of psychological dependence of the so-called ＂ 1 ＋ 1 ＂ compound （the elements are buprenorphine, scopolamine and promethazine）. Methods One hundred and sixtyone male Sprague-Dawley rats were randomly assigned to 9 groups： buprenorphine, scopolamine, promethazine, buprenorphine plus scopolamine, buprenorphine plus promethazine, buprenorphine plus scopolamine and promethazine, scopolamine plus promethazine, morphine and saline groups respectively. All the 9 groups were trained by using the conditioned place preference （CPP） paradigm for 10 days. Results The rats in the five groups treated with buprenorphine alone or in combination with scopolamine/promethazine and morphine developed CPP. The time change spent by the rats in the buprenorphine plus scopolamine and promethazine group are （ 378.6 ± 120.8） s , apparently longer than that by the rats in the buprenorphine group （ 302.2 ± 133.9 ） s, but compared with that by rats in the morpine group（419.8± 146.4） s, there is no significant difference（ F= 14.3, P = 0.63）. Conclusion The combination use of buprenorphine plus scopolamine and promethazine may act synergistically, and scopolamine and prornethazine may enhance psychological dependence of buprenorphine.
出处
《中国行为医学科学》
CSCD
2008年第4期298-300,共3页
Chinese Journal of Behavioral Medical Science
基金
国家重大发展研究基础（973）计划资助项目（CB2003515403,CB2003515404）
