WWOX蛋白在大肠癌中的表达及意义

Expression and significance of WWOX protein in colorectal carcinomas

目的探讨WWOX(WW domain containing oxidoreductase)蛋白在大肠癌的表达及与生物学行为的关系。方法应用免疫组化EnVision二步法检测WWOX蛋白在58例大肠癌及20例大肠炎症中的表达水平。结果WWOX蛋白在大肠癌中的阳性率为25.86%(15/58),在炎症中的阳性率为65%(13/20),两者间的差异具有统计学意义(P<0.01),WWOX在癌组织的表达低于对照组。另外在大肠癌中WWOX蛋白的表达与浸润深度及预后相关,差异有统计学意义(P<0.05,P<0.01),但其与性别、年龄等其他临床病理参数无关。结论WWOX蛋白可能参与调控大肠癌的发生、发展,且在大肠癌的预后诊断中扮演重要角色。

Objective To study the relationship between the expression of WWOX（ WW domain containing oxidoreductase）protein and its biological behavior. Methods 58 cases of colorectal carcinoma tissues and 20 cases of colorectal inflammatory were examined by Envision immunohistochemical staining. Results The positive rate of WWOX protein was 25.86 % （ 15/58 ） and 65 % （13/20）in colorectal inflammatory.There existed significant difference between the two groups（ P 〈 0.01 ）. The positive rate of WWOX protein was lower in tumor than that in colorectal inflammatory. The positive rate of WWOX protein in patients with lower five-years survival rate were significantly lower than those in patients with higher five-years survival rate （ P 〈 0. 01 ）, and a significant difference of expression of WWOX in invasion in colorectal carcinomas（ P 〈 0.05）was found.The expression of WWOX in colorectal carcinoma was not significantly related to the sex of patients or the age of patients and so on （ P 〉 0.05）. Conclusion WWOX correlates with occurrence and development of colorectal carcinoma. And WWOX plays a key role in the prognosis of colorectal carcinoma.