摘要
应用免疫组化LSAB法技术以FⅧ因子相关抗原标记血管内皮细胞对199例原发性肺癌组织内微血管进行了定量观察,结果表明:淋巴结有转移组的肺癌微血管密度为53.6±24.2个/200×,无转移组的为35.7±19.8个/200×;淋巴结有转移组的微血管腔面积为5181.2±2522.4,无转移组为3491.1±2083.7,两者在两组间差异均具显著性(P<0.01,P<0.02)。微血管密度在5年以上生存组为32.7±20.8个/200×,半年内死亡组为49.1±30.5个/200×,两者差异具有显著性意义(P<0.01),微血管腔面积在三组不同生存期的患者间差异亦具显著性(P<0.01),腔面积不同,术后生存时间不同,提示微血管定量分析可以作为临床判断肺癌预后的指标之一。
Microvessel quantitation in 199 cases of primary lung cancer wereanalysed by LSAB using antibody against factor VIII-related antigen- The resultsshowed that the microvessel count in node-positive group was 53. 6± 24. 2 and thatin node-negative group was 35. 7± 19. 8-The difference was apparent (P<0. 01).The sum of vascular calibre area was also significantly different between the twogroups 5181. 2± 2522. 4 vs 3491. 1 ±2083. 7 respectively (P<0. 02). The microvessel count in patients lived for more than 5 years was 32. 7 ± 20. 8, while in thegroup died within half a year was 49. 1±30. 5 (P<0. 01). It is indicated quantitation of microvessel is a useful parameter in predicting the prognosis of patients withlung cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第10期725-727,共3页
Chinese Journal of Clinical Oncology
关键词
肺肿瘤
微血管
定量
预后
转移
Lung cancer Microvessel Quantitation Prognosis Metastasis