肺癌微血管定量分析与预后的关系

Microvessel Quantification and Prognosis in Primary Lung Cancer

应用免疫组化LSAB法技术以FⅧ因子相关抗原标记血管内皮细胞对199例原发性肺癌组织内微血管进行了定量观察，结果表明：淋巴结有转移组的肺癌微血管密度为53．6±24．2个／200×，无转移组的为35．7±19．8个／200×；淋巴结有转移组的微血管腔面积为5181．2±2522．4，无转移组为3491．1±2083．7，两者在两组间差异均具显著性（P＜0．01，P＜0．02）。微血管密度在5年以上生存组为32．7±20．8个／200×，半年内死亡组为49．1±30．5个／200×，两者差异具有显著性意义（P＜0．01），微血管腔面积在三组不同生存期的患者间差异亦具显著性（P＜0．01），腔面积不同，术后生存时间不同，提示微血管定量分析可以作为临床判断肺癌预后的指标之一。

Microvessel quantitation in 199 cases of primary lung cancer wereanalysed by LSAB using antibody against factor VIII-related antigen- The resultsshowed that the microvessel count in node-positive group was 53. 6± 24. 2 and thatin node-negative group was 35. 7± 19. 8-The difference was apparent (P＜0. 01).The sum of vascular calibre area was also significantly different between the twogroups 5181. 2± 2522. 4 vs 3491. 1 ±2083. 7 respectively (P＜0. 02). The microvessel count in patients lived for more than 5 years was 32. 7 ± 20. 8, while in thegroup died within half a year was 49. 1±30. 5 (P＜0. 01). It is indicated quantitation of microvessel is a useful parameter in predicting the prognosis of patients withlung cancer.