网织红细胞及其组份测定在实体肿瘤化疗中的应用

Forecast of Granulocytopenia and Its Recovery during Cancer Chemotherapy

网织红细胞（Ret）是成熟红细胞的前体，根据其RNA含量的不同可分为低荧光率（LFR）、中荧光率（MFR）和高荧光率（HFR）三种组份，用SysmexR－3000TM流式细胞仪对32例肿瘤患者化疗前后的Ret及其三种组份进行测定，并对照血常规的检查。研究结果表明：Ret比WBC和Plat的减少平均提前4天出现降低，MFR＋HFR比WBC的恢复平均提前3天出现升高。由此看出Ret及MFR＋HFR是预测骨髓抑制及恢复的一个敏感指标，对指导临床用药有一定作用。

Fractional count of reticulocyte was done in 32 patients with lungand gastric cancer undergoing chemotherapy. It was revealed that reticulocytic countbegan to decrease averagely 4 days prior to the occurrence of granulocytopenia andthrombocytopenia, and that the middle fluorescence ratio (MFR) plus high fluorescence ratio (HFR) of the reticulocyte rose 3 days before the recovery of neutrophils. Thus, the reticulocyte and its fractional count may act as an forerunner ofgranulocytopenia as well as it's recovery,and might be a sensitive harbinger in tumor chemotherapy.