Granocyte在妇科肿瘤化疗期间及外周血干细胞移植中的应用

Role of Granocyte during Chemotherapy and Transplantation after Intensive Chemotherapy

研究G－CSF（Granulocyte－ColonyStimulatingFactor）即粒细胞集落刺激因子在化疗中对粒细胞的刺激作用。方法：观察20例肿瘤患者化疗期间应用小剂量Granocyte（1～2μg／kg／日）治疗化疗引起的白细胞减少及应用大剂量Granocyte（5μg／kg／日），在超大剂量化疗外周血干细胞移植时的干细胞动员。A组：46个周期，为停化疗2周白细胞低于3．5×109时给小剂量G－CSF（1～2μg／kg／日）；C组：9个周期，为停化疗24小时后给小剂量G－CSF（1～2μg／kg／日）；B组：不给G－CSF，为对照组。结果：A组给药2～3天后白细胞可达5×109／L以上，C组化疗后白细胞未降至3×109／L以下。观察中同时发现大剂量G－CSF对血小板减少也有治疗作用。结论：G－CSF对化疗后白细胞降低有较好的治疗作用。

Objective: To study the granulocyte stimulating effects of Granocyte (G-CSF) during chemotherapy. Methods: Small dose Granocyte dealingwith chemotherapy-induced leucocytopenia, and large dose Granocyte in mobilizingtransplanted leucocytic stem cells under intensive chemotherapy were observed in20 patients with gynecologic cancers. For patients in group A after two weekschemotherapy, 1 to 2μg/day of G-CSF was given with WBC less than 3. 5 × 109.For patients in group C 24 hours after chemotherapy, 1μg/kg/day of G-CSF wasgiven. Group B patients were used as control. Results: In group A patient's WBCexceeded 5 × 109 in 2 to 3 days after medication. In group C patientsf, there was nodecrement of WBC below 3 × 109. Large dose of G-CSF has the therapeutic effecton thrombocytopenia as well. Conclusion: G-CSF has remarkable effect onchemotherapy-induced leucocytopenia.