迟发性运动障碍与血清尿酸的关系

Relationship between serum uric acid and tardive dyskinesia

目的:观察伴迟发性运动障碍(TD)的精神分裂症患者血清尿酸变化,探索尿酸与TD的关系。方法:采用尿酸酶法测定23例TD患者、相匹配的23例非TD患者及24例正常对照的血清尿酸水平,使用异常不自主运动量表(AIMS)评定TD的严重程度。结果:TD组血清尿酸水平显著低于非TD组及对照组(P均<0.01),而非TD组与对照组之间血清尿酸水平无差异。TD组中AIMS评分与血清尿酸水平呈负相关(r=-0.435,P<0.05)。结论:TD患者存在低血清尿酸水平并与TD的严重程度有关,尿酸可能参与了TD的病理生理过程。

Objective：To observe the change of sermn uric acid in schizophrenic patients with tardive dyskinesia （TD） and to explore the relationship between uric acid and TD. Method： Levels of serum uric acid were measured by uricase method in 23 TD patients,23 matched non-TD patients and 24 normal controls. Severity of TD was assessed with the abnormal involuntary movement scale （AIMS）. Results： Compared with non-TD group and control group,the level of sermn uric acid was significantly lower in TD group （all P 〈 0.01） ,while no difference was shown between non-TD group and control group. In TD group,scores of AIMS were negatively correlated with level of sermn uric acid （ r = -0.435, P 〈 0.05）. Conclusion： TD patients have lower level of sermn uric acid which is related to the severity of TD. Uric acid may be involved in the pathophysiological process of TD.