精神分裂症遗传的性别差异

The hereditary gender difference for schizophrenia

目的:比较不同性别精神分裂症遗传的差异。方法:在同期出院的877例精神分裂症患者中,整群连续抽取精神分裂症阳性家族史患者107例:按性别分为男性组45例,女性组62例。对家族史阳性率,先证者父系、母系、同胞、子女患病情况,一、二、三级亲属患病情况,胎次,患病个数及疗效作统计分析。结果:男性阳性家族史比率较女性低,且疗效差异有显著性;女性患者4胎及以上者显著较多。结论:不同性别精神分裂症的遗传有差异。

Objective：To compare the hereditary gender difference for schizophrenia. Method：We sampled 107 schizophrenic patients with mental disorder family history from 877 patients with schizophrenia discharged from hospital at same period by cluster sampling. These patients were divided into male group （ n = 54） and female group （ n = 62）. We made an analysis in mental disorder family history, condition of suffering from mental disorder in patrilineal, maternal, sibling and children of the probands and in probands＇ relatives of fast-degree, second-degree and third-degree, fetal order, total sick number and efficacy. Results：Positive mental disorder family history was lower in male group compared with female group, with significant difference in efficacy in the two groups. Female patients obviously tended to have four or more siblings in their families. Conclusion：There were some hereditary gender differences for schizophrenia.